Alzheimer's disease

Epidemiological clues and genotyping data from tens of thousands of individuals with or without Alzheimer's led to an age-specific polygenic risk score.

The funding builds on more than $1.7 million already awarded to the firm, which is building a diagnostic for characterizing patients in clinical trials.

The study will involve assaying proteomic markers for dementias including Alzheimer's disease, and understanding genomic markers as part of the normal aging process.

This Week in Cell

In Cell this week: essential genes in AML, indel hotspots affect certain genes in cancer, and more.

The Familial Mutation

Researchers are studying people with familial early-onset Alzheimer's disease to gain insight into the disease, NPR reports.

The study, which used mass spec to analyze 129 human brain tissue samples, is part of a larger $7.2 million project funded by the National Institute on Aging.

This Week in PNAS

In PNAS this week: genes involved in histone deacetylation in Arabidopsis, effects of pathogenic presenilin-1 mutations, and more.

The findings run counter to the traditional understanding of tau's role in Alzheimer's, which holds that modified forms of the protein help drive the disease.

The funding will support research into the roles Alzheimer's disease-associated genetic variants play in neural cell biology.

An exome-wide association study drew attention to a rare variant in TM2D3 that is more common among people of Icelandic heritage.

Pages

The Chan Zuckerberg Initiative is investing in Cold Spring Harbor Laboratory's BioRxiv.

A study appearing in PLOS One finds that shortened consent forms don't affect clinical trial participants' understanding of the study.

The National Security Agency monitored signal intelligence for signs of "nefarious" genetic engineering projects, Gizmodo reports.

In Nature this week: barley genome sequenced, method for genotyping and phasing short tandem repeats, and more.