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Alzheimer's disease

In Science this week: approach to infer genotype-by-environment interaction from genetic variants associated with phenotypic variability, and more.

And Now You Know

NPR speaks with research participants before and after they learn their APOE E4 status, which affects their risk of developing Alzheimer's disease.

Of participants with high genetic risk, 1.13 percent with a favorable and 1.78 percent with an unfavorable lifestyle developed dementia over a median eight years.

Individuals with Alzheimer's disease are enriched for somatic mutations in brain tissue that affect tau-related pathways, as compared to unaffected individuals.

Giving It a Try

Massive Science writes that tool like CRISPR could help treat diseases like Alzheimer's, but more likely will help researchers understand such conditions better first.

The researchers found that dark regions impact more than 700 protein-coding genes and also identified a novel mutation in a known Alzheimer's disease gene.

In Genome Biology this week: study of 'dark' genome regions, algorithm to determine DNA methylation variation, and more.

Using exome data from Alzheimer's disease cases and controls with or without the APOE4 risk allele, investigators identified potential risk-stratifying variants.

The Massachusetts Institute of Technology-led team uncovered cell-type-specific transcriptional changes that occur early on in disease development.

To understand the evolution of brain conditions and other traits, investigators plan to sequence human and pathogen DNA in thousands of samples from Europe.

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Holden Thorp is to be the new editor-in-chief of Science and its related journals.

A genetic analysis of salmon scales collected over the course of a century points to a sharp decline in the number of fish returning each year to river in British Columbia, CBC reports.

Adelaide University has suspended the head of an ancient DNA lab as its investigation of workplace bullying continues, Australia's ABC News reports.

In PNAS this week: gene expression profiles of adipocyte subtypes, computational approach for improving plant expressome analysis, and more.