Amyotrophic Lateral Sclerosis Protective Variants Proposed in Untranslated Gene Region
By comparing rare variants in untranslated regions from ALS cases and controls, researchers focused in on an IL18RAP 3' UTR that appeared to reduce ALS risk.
DNA Methylation Differences in Amyotrophic Lateral Sclerosis Point to Risk Pathways
An epigenome-wide association meta-analysis highlighted 45 differentially methylated positions in ALS patient blood samples, offering insights into related pathways and traits.
More Than Dozen Genetic Loci Linked to Amyotrophic Lateral Sclerosis Risk
The risk loci highlight shared ties and differences between ALS and other neurodegenerative conditions, and further suggested a role for autophagy in ALS development.
Multiomic Analysis of ALS Pinpoints Altered Lipid Metabolism as Potential Therapeutic Target
Researchers analyzed spinal motor neurons and ocular motor neurons to identify shared metabolic perturbations in inherited and sporadic ALS.
New ALS Risk Gene Suggests Role for Apoptosis
Rare variants in the TP73 gene affect protein function, increase apoptosis, and lead to the impaired development of motor neurons, according to a new study.