ALS

Verge is working with four academic institutions to create a broad resource for the translation of preclinical models of amyotrophic lateral sclerosis research.

Investigators identified changes in methylation at neurobiology-related genes when comparing blood methylation in twin pairs discordant for ALS.

The researchers observed that eliminating these microsatellite repeat expansion RNAs in patient cells reversed some hallmark features of the diseases.

Researchers found that about 17 percent of sporadic amyotrophic lateral sclerosis patients harbor at least one deleterious rare variant or repeat expansion.

Rare mutations in the ANXA11 gene showed up in cases with familial and sporadic forms of amyotrophic lateral sclerosis.

Poly(GP) proteins could be detected within ALS patients samples and used to determine whether ALS drugs under development are reaching their targets.

Experts led by Duke neuroscientist Allen Roses developed the database hoping to boost researchers' ability to explore the role of short structural variants in complex diseases. 

This Week in Nature

In Nature this week: variant linked to obesity risk in Samoans, health of cloned animals, and more.

The researchers particularly highlighted C21orf2 and NEK1, which are involved in cilial and mitochondrial function.

This Week in Science

In Science this week: genomes from the Fertile Crescent give insight into early farmers, and more.

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The Jackson Laboratory has filed a complaint accusing Nanjing University of breeding and re-selling its mouse models, the Hartford Courant reports.

Oxford researchers are turning to virtual reality to visualize genes and regulatory elements, Phys.org says.

In Science this week: neutrophils rely on microRNA to protect against lung inflammation, and more.

China is moving forward with plans to sequence a million citizens, the Wall Street Journal reports.