aging

A null mutation in the SERPINE1 gene was associated with longer telomeres and increased longevity among carriers, a new study found.

For Long Life

A new sample of supercentenarian genomes is to be available to researchers this week, the New York Times reports.

Bioage Labs now intends to set up an internal laboratory to experiment with different compounds, while building out its team.

With discovery and replication meta-analyses on data for more than 100,000 individuals, researchers identified variants that influence lean mass near five genes.

Researchers saw partial overlap between variants influencing age-related methylation and neuronal patterns and those implicated in other traits or diseases.

Variants affecting Alzheimer's risk, cholesterol levels, and more also affect human longevity, according to a speaker at the Biology of Genomes meeting.

The technology is based on the work of UCLA's Steve Horvath, who has shown that DNA methylation age could predict all-cause mortality later in life.

A comparison of unstimulated and stimulated CD4+ T cells from young and old mice in two subspecies showed rising cell-to-cell expression variability with age.

Columbia University researchers uncover a gene variant associated with differential aging in the brain after the age of 65.

The study will involve assaying proteomic markers for dementias including Alzheimer's disease, and understanding genomic markers as part of the normal aging process.

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The US Food and Drug Administration has new guidelines that enable some gene and cell therapies to undergo expedited review, according to the New York Times.

Using gene drives to control invasive species might be too risky, an initial advocate of the approach says.

In Science this week: intellectual property experts argue patent battles such as the one over CRISPR are wasteful, and more.

Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.