The Long Life Family Study has enrolled 4,953 participants in 539 pedigrees in the US and Denmark that are enriched for exceptional longevity.
From single-cell RNA sequence data on neurogenic brain samples from young and old mice, researchers saw T cell activity that seems to staunch neural stem cell proliferation.
In Genome Research this week: links between biological aging and mutations affecting epigenetic regulators; long-read sequencing-based strategy to map chromatin accessibility; and more.
The long-running Framingham Heart Study has received a $38 million grant, according to the Boston Globe.
Some of the mutational signatures the researchers observed were similar to ones previously seen in B cell tumors, underscoring the link between aging and cancer.
Investigators found methylation models in conserved ribosomal DNA from mice also showed promise as age predictors in canine and human samples.
The company is developing a methylated DNA biomarker that will predict all-cause mortality risk and risk of developing certain age-related diseases.
Researchers uncover additional loci associated with lifespan, which the Telegraph says could be folded into a genetic test.
DNA sequence data from hundreds of individuals suggest that age, smoking, and alcohol use coincide with the expansion of clones containing NOTCH1 and PPM1D mutations.
In Genome Biology this week: catalog of curated human genes and transcripts; potential biomarkers for aging; and more.
The Wall Street Journal looks into FamilyTreeDNA's handling of genetic genealogy searches by law enforcement.
In a point-counterpoint in the Boston Globe, researchers discuss the potential of gene editing to prevent Lyme disease, but also the pitfalls of doing so.
MIT's Technology Review reports that researchers hope to develop a CRISPR-based pain therapy.
In Science this week: atlas of malaria parasites' gene expression across their life cycles, and more.