Chromatin immunoprecipitation sequencing showed divergent H4K16ac histone acetylation patterns in brain samples from young, old, and AD-affected individuals.

Long Lives of Bats

Researchers report that the telomeres of a long-lived bat don't shorten with age.

This Week in Nature

In Nature this week: nanopore sequencing and assembly human genome, method to reduce CRISPR off-target effects, and more.

As organisms age, their transcriptomic signatures shift from looking more like those observed in cancer to those seen in degenerative chronic diseases.

Research teams documented mosaic mutations during brain development, as well as rising somatic mutations in aging brains or brains affected by neurodegenerative disease.

A null mutation in the SERPINE1 gene was associated with longer telomeres and increased longevity among carriers, a new study found.

For Long Life

A new sample of supercentenarian genomes is to be available to researchers this week, the New York Times reports.

Bioage Labs now intends to set up an internal laboratory to experiment with different compounds, while building out its team.

With discovery and replication meta-analyses on data for more than 100,000 individuals, researchers identified variants that influence lean mass near five genes.

Researchers saw partial overlap between variants influencing age-related methylation and neuronal patterns and those implicated in other traits or diseases.


An opinion piece in the Guardian argues that President Donald Trump is uninterested in science and that might not be a bad thing for the field.

The San Francisco Chronicle reports the Veterans Affairs Health System is studying whether genetic testing can help prescribe better depression therapies.

Stat News reports that Spark Therapeutics' Luxturna is now being used to treat a wider array of patients.

In Genome Biology this week: transcription factor use among brittle stars, single-cell RNA sequencing strategy, and more.