aging

An Australian team has sequenced some 4,000 healthy individuals over 70 years old for the Medical Genome Reference Bank database.

Researchers saw frequent somatic mutations in esophageal tissue from nine individuals, including mutations under positive selection in 14 oncogenes.

This Week in PNAS

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.

And That's It

Business Insider reports that a three-year partnership between Ancestry and Calico has ended.

The researchers were able to diagnose 17 patients with short telomere syndrome based on telomere length combined with targeted sequence data.

Using a mass cytometry method called EpiTOF, researchers profiled histone modifications and variants in a range of immune cell types across individuals of different ages.

Chromatin immunoprecipitation sequencing showed divergent H4K16ac histone acetylation patterns in brain samples from young, old, and AD-affected individuals.

Long Lives of Bats

Researchers report that the telomeres of a long-lived bat don't shorten with age.

This Week in Nature

In Nature this week: nanopore sequencing and assembly human genome, method to reduce CRISPR off-target effects, and more.

As organisms age, their transcriptomic signatures shift from looking more like those observed in cancer to those seen in degenerative chronic diseases.

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Though many details have yet to be worked out, the draft deal for the UK's withdrawal from the EU is giving researchers some hints for what they can expect, Nature News says.

DNA testing has solved a 100-year-old mystery contained in the skull and teeth samples of a now-extinct monkey that once inhabited Jamaica, Gizmodo reports.

As the UN ponders a ban on gene drives, one malaria researcher says there are less dramatic ways to fight the disease in Africa than unleashing GM mosquitoes on a whole continent.

In Nature this week: an improved reference genome of the Aedes aegypti mosquito, genomes of four species of truffles, and more.