adverse events
New IBD Adverse Drug Response Risk Gene Identified
Genome- and exome-wide association analysis on inflammatory bowel disease patients with or without thiopurine-induced myelosuppression revealed new and known risk genes.
Warfarin Bleeding Risk SNPs Identified in African Americans
A case-control GWAS of individuals of African descent led to four chromosome 6 SNPs with apparent ties to bleeding risk associated with warfarin anticoagulants.
The effort is already bearing fruit, as the team has been able to validate several variants known to be connected with adverse drug reactions.
Backed by €15 million in EU funding, the Ubiquitous Pharmacogenomics Consortium seeks to implement preemptive testing at seven healthcare systems by 2020.
Gene Variant Linked to Childhood Cancer Drug's Cardio Side Effects
An international team detected a variant associated with anthracycline-induced cardiotoxicity in a study of more than 450 children treated with the drug.