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adverse events

Genome- and exome-wide association analysis on inflammatory bowel disease patients with or without thiopurine-induced myelosuppression revealed new and known risk genes.

A case-control GWAS of individuals of African descent led to four chromosome 6 SNPs with apparent ties to bleeding risk associated with warfarin anticoagulants.

The effort is already bearing fruit, as the team has been able to validate several variants known to be connected with adverse drug reactions.

Backed by €15 million in EU funding, the Ubiquitous Pharmacogenomics Consortium seeks to implement preemptive testing at seven healthcare systems by 2020.

Slow Report

National Cancer Institute researchers didn't report severe adverse events to Food and Drug Administration in a timely manner, the Wall Street Journal reports.

An international team detected a variant associated with anthracycline-induced cardiotoxicity in a study of more than 450 children treated with the drug.

The study provides a public list of ADRs ranked by severity and highlights the efficacy of crowd-sourcing for pharmacovigilance studies.

NEW YORK (GenomeWeb News) – HemoShear today announced a partnership with Expression Analysis to develop a database for evaluating the vascular pharmacology of new drug compounds.

The International Severe Adverse Event Consortium will collaborate with CHI's Center for Translational Research to identify genetic markers for adverse drug reactions.

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The New York Times Magazine examines gender discrimination at the Salk Institute.

Science reports that MD Anderson Cancer Center has dismissed three researchers over foreign tie concerns.

A second death in gene therapy trial for type 1 spinal muscular atrophy is under investigation, according to Reuters.

In PLOS this week: antibiotic resistance patterns in Escherichia coli, a dozen genetic loci tied to varicose vein risk, and more.