adverse events

A case-control GWAS of individuals of African descent led to four chromosome 6 SNPs with apparent ties to bleeding risk associated with warfarin anticoagulants.

The effort is already bearing fruit, as the team has been able to validate several variants known to be connected with adverse drug reactions.

Backed by €15 million in EU funding, the Ubiquitous Pharmacogenomics Consortium seeks to implement preemptive testing at seven healthcare systems by 2020.

Slow Report

National Cancer Institute researchers didn't report severe adverse events to Food and Drug Administration in a timely manner, the Wall Street Journal reports.

An international team detected a variant associated with anthracycline-induced cardiotoxicity in a study of more than 450 children treated with the drug.

The study provides a public list of ADRs ranked by severity and highlights the efficacy of crowd-sourcing for pharmacovigilance studies.

NEW YORK (GenomeWeb News) – HemoShear today announced a partnership with Expression Analysis to develop a database for evaluating the vascular pharmacology of new drug compounds.

The International Severe Adverse Event Consortium will collaborate with CHI's Center for Translational Research to identify genetic markers for adverse drug reactions.

The iSAEC this week announced a partnership with Shanghai Jaio Tong University to study serious drug reactions in Chinese populations, expanding the group's understanding of the impact of ethnic diversity on genomically influenced adverse events with a strong immunological underpinning.

Pages

Hundreds of scientists have signed a letter criticizing the open-access Plan S, ScienceInsider reports.

NPR speaks with Rep. Eddie Bernice Johnson (D-Texas) about the US House of Representatives science committee.

A start-up company aiming to match cancer patients to treatments closes after about six weeks, Stat News reports.

In PLOS this week: somatic mutation associations unearthed in thousands of cancer exomes, pathogen detection assay, and more.