Skip to main content
Premium Trial:

Request an Annual Quote

William Blair Initiates Coverage of Exact Sciences

By a GenomeWeb staff reporter

NEW YORK (GenomeWeb News) – Investment firm William Blair initiated coverage of Exact Sciences with an "Outperform" rating and "Aggressive growth" company profile.

Analyst Brian Weinstein rated the Madison, Wis.-based molecular diagnostics firm based on the "enormous" market opportunity that exists for its Cologuard stool-based DNA colorectal cancer screening test. He cited the need for an accurate, non-invasive test, as well as encouraging early data on the test's performance and management's experience running large pre-market approval trials as reasons for the positive outlook.

Exact Sciences is currently developing the test and expects to file for clearance from the US Food and Drug Administration in 2012. Weinstein predicted that clearance would come in 2013.

Last month, the company raised $64.7 million in a public offering to support clinical trials for the test and to carry out "strategic initiatives."

In late-October, Exact Sciences presented data from a validation study for Cologuard. Weinstein said that though the firm has no other test in the pipeline or for sale, and any problems with the clinical study of Cologuard or its commercialization would be "a major issue, we believe this name offers significant value to investors patient enough to be rewarded, owing to the differentiated product and immense market opportunity."

The Scan

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.

Tibetan Study Finds Adaptive Variant Influencing Skin Pigmentation

With a combination of phenotyping and genetic data, researchers document at PNAS a Tibetan-enriched enhancer variant influencing melanin synthesis and ultraviolet light response.

Domestication Linked to Nervous System Genes in Inbred Mouse Strains

Researchers highlighted more than 300 positively selected genes in domesticated mice, including genes linked to nervous system function or behavior in Genome Biology.

ALS Genetic Testing May Be Informative Across Age Ranges, Study Finds

Researchers in the journal Brain identified clinically actionable variants in a significant subset of older ALS patients, prompting them to point to the potential benefits of broader test use.