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Ventana to Develop Companion Dx for Pfizer NSCLC Drug

NEW YORK (GenomeWeb News) – Ventana Medical Systems has struck a collaboration agreement with Pfizer and a license pact with Cell Signaling Technology to develop an automated companion diagnostic test for determining which non-small cell lung cancer patients will respond to a new Pfizer drug.

The immunohistochemistry test Ventana will develop will identify NSCLC patients with rearrangements of the anaplastic lymphoma receptor tyrosinekinase, or ALK, gene. Such patients may benefit from crizotinib, marketed by Pfizer as Xalkori.

The Ventana ALK IHC test will be based on CST's D5F3 antibody and Ventana's OptiView DAB detection technologies, and it will be performed on Ventana's automated platforms.

"Our early development data suggests that the combination of CST's D5F3 antibody and Ventana's OptiView detection generates a highly sensitive assay that detects cases with very low expression of the ALK protein in lung tissue," Ventana's President Mara Aspinall said in a statement.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.