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In Print: Recent Pharmacogenomics Papers of Note: Jan 15, 2014


Building pharmacogenetics into a pharmacovigilance program in Singapore: using serious skin rash as a pilot study.
Toh DS, Tan LL, Aw DC, et al.
Pharmacogenomics J. 2014 Jan 7. [Epub ahead of print]

Detecting signals in pharmacogenomic genome-wide association studies.
Wakefield J, Skrivankova V, Hsu FC, et al.
Pharmacogenomics J. 2014 Jan 7. [Epub ahead of print]

Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients.
Tessari A, Palmieri D, Di Cosimo S.
Pharmgenomics Pers Med. 2013 Dec 16;7:1-19.

Clopidogrel metaboliser status based on point-of-care CYP2C19 genetic testing in patients with coronary artery disease.
Erlinge D, James S, Duvvuru S, et al.
Thromb Haemost. 2014 Jan 9;111(5). [Epub ahead of print]

Pharmacogenomic characterization of gemcitabine response - a framework for data integration to enable personalized medicine.
Harris M, Bhuvaneshwar K, Natarajan T, et al.
Pharmacogenet Genomics. 2014 Feb;24(2):81-93.

Molecular and Genetic Diversity in the Metastatic Process of Melanoma.
Harbst K, Lauss M, Cirenajwis H, et al.
J Pathol. 2014 Jan 7. [Epub ahead of print]

Assessing the Integration of Genomic Medicine in Genetic Counseling Training Programs.
Profato J, Gordon ES, Dixon S, Kwan A.
J Genet Couns. 2014 Jan 8. [Epub ahead of print]

Approval gap of pharmacogenomic biomarkers and in vitro companion diagnostics between the United States and Japan.
Shimazawa R, Ikeda M.
J Clin Pharm Ther. 2014 Jan 10. [Epub ahead of print]

Targeted therapy pretreatment helps chemotherapy for aggressive lymphoma.
Printz C.
Cancer. 2014 Jan 1;120(1):3.

Pharmacogenetics of methotrexate in acute lymphoblastic leukaemia: why still at the bench level?
Kodidela S, Suresh Chandra P, Dubashi B.
Eur J Clin Pharmacol. 2013 Dec 27. [Epub ahead of print]

Pharmacogenetics: Implications of race and ethnicity on defining genetic profiles for personalized medicine.
Ortega VE, Meyers DA.
J Allergy Clin Immunol. 2014 Jan;133(1):16-26.

Genomics, personalized medicine, and pediatrics.
Feero WG, Guttmacher AE.
Acad Pediatr. 2014 Jan-Feb;14(1):14-22.

Molecularly targeted cancer therapy: some lessons from the past decade.
Huang M, Shen A, Ding J, Geng M.
Trends Pharmacol Sci. 2014 Jan;35(1):41-50. Epub 2013 Dec 19.

What is personalized medicine: sharpening a vague term based on a systematic literature review.
Schleidgen S, Klingler C, Bertram T, et al.
BMC Med Ethics. 2013 Dec 21;14(1):55.

Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.
Balko JM, Giltnane J, Wang K, et al.
Cancer Discov. 2013 Dec 19. [Epub ahead of print]

Pharmacogenomics in psychiatry: the relevance of receptor and transporter polymorphisms.
Reynolds GP, McGowan OO, Dalton CF.
Br J Clin Pharmacol. 2013 Dec 19. [Epub ahead of print]

Genetic Profiling to Determine Risk of Relapse Free Survival in High-risk Localized Prostate Cancer.
Barnett CM, Heinrich MC, Lim J, et al.
Clin Cancer Res. 2013 Dec 18. [Epub ahead of print]

The Scan

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.

Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets

Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.