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In Print: Recent PGx Papers of Note, May 28, 2014


Navigating the Rapids: The Development of Regulated Next-Generation Sequencing-Based Clinical Trial Assays and Companion Diagnostics.
Pant S, Weiner R, Marton MJ.
Front Oncol. 2014 Apr 17;4:78.

Diagnostic and therapeutic issues for patients with advanced non?small cell lung cancer harboring anaplastic lymphoma kinase rearrangement: European vs. US perspective (Review).
Di Maio M, De Marinis F, Hirsch FR, Gridelli C.
Int J Oncol. 2014 May 21. [Epub ahead of print]

Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis.
Miao R, Luo H, Zhou H, Li G, et al.
J Hepatol. 2014 May 22. [Epub ahead of print]

The 12th annual pharmacogenetics in psychiatry meeting report.
Zhang JP, Aitchison KJ, Malhotra AK.
Psychiatr Genet. 2014 May 22. [Epub ahead of print]

Development of a Multiplex and Cost-Effective Genotype Test toward More Personalized Medicine for the Antiplatelet Drug Clopidogrel.
Jeong HE, Lee SJ, Cha EY, et al.
Int J Mol Sci. 2014 May 5;15(5):7699-7710.

Biomarkers and personalized therapy in chronic kidney diseases.
Schena FP.
Expert Opin Investig Drugs. 2014 May 26:1-4. [Epub ahead of print]

Pharmacogenetic biomarkers for predicting drug response.
Bank PC, Swen JJ, Guchelaar HJ.
Expert Rev Mol Diagn. 2014 May 24:1-13. [Epub ahead of print]

Impact of point-of-care testing for CYP2C19 on platelet inhibition in patients with acute coronary syndrome and early dual antiplatelet therapy in the emergency setting.
Stimpfle F, Karathanos A, Droppa M, et al.
Thromb Res. 2014 May 10. [Epub ahead of print]

ERCC1, XRCC1 and GSTP1 Single Nucleotide Polymorphisms and Survival of Patients with Colon Cancer Receiving Oxaliplatin-Based Adjuvant Chemotherapy.
Zaanan A, Dalban C, Emile JF, et al.
J Cancer. 2014 May 2;5(6):425-32.

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Zhang B, Jia WH, Matsuda K, et al.
Nat Genet. 2014 May 18. doi: 10.1038/ng.2985. [Epub ahead of print]

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The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.