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In Print: Pharmacogenomics Papers of Note


Expanding the Foundation for Personalized Medicine: Implications and Challenges for Dentistry.
Garcia I, Kuska R, Somerman MJ.
J Dent Res. 2013 May 20 [Epub ahead of print]

Pharmacogenomic Association of Nonsynonymous SNPs in SIGLEC12, A1BG, and the Selectin Region and Cardiovascular Outcomes.
McDonough CW, Gong Y, Padmanabhan S, et al.
Hypertension. 2013 May 20. [Epub ahead of print]

Pharmacogenomics and Cardiovascular Disease.
Weeke P, Roden DM.
Curr Cardiol Rep. 2013 Jul;15(7):376.

EGFR Tyrosine Kinase Inhibitors: Difference in Efficacy and Resistance.
Robinson KW, Sandler AB.
Curr Oncol Rep. 2013 May 16. [Epub ahead of print]

microRNA expression profile in stage III colorectal cancer: Circulating miR-18a and miR-29a as promising biomarkers.
Brunet A, Pericay C, Moya I, et al.
Oncol Rep. 2013 May 15. [Epub ahead of print]

Circulating melanoma cells as a predictive biomarker.
Karakousis G, Yang R, Xu X.
J Invest Dermatol. 2013 Jun;133(6):1460-2.

Use of pharmacogenetics for predicting cancer prognosis and treatment exposure, response and toxicity.
Hertz DL, McLeod HL.
J Hum Genet. 2013 May 16. [Epub ahead of print]

Targeted therapy with kinase inhibitors in aggressive endocrine tumors.
Marotta V, Franzese MD, Del Prete M, et al.
Expert Opin Pharmacother. 2013 Jun;14(9):1187-203.

Warfarin pharmacogenomics in children.
Vear SI, Stein CM, Ho RH.
Pediatr Blood Cancer. 2013 May 16. [Epub ahead of print]

Personalized medicine in psychiatry: problems and promises.
Ozomaro U, Wahlestedt C, Nemeroff CB.
BMC Med. 2013 May 16;11(1):132. [Epub ahead of print]

A simple and reproducible breast cancer prognostic test.
Marchionni L, Afsari B, Geman D, Leek JT.
BMC Genomics. 2013 May 17;14(1):336. [Epub ahead of print]

Expression of PTEN and mTOR in pancreatic neuroendocrine tumors.
Han X, Ji Y, Zhao J, Xu X, Lou W.
Tumour Biol. 2013 May 19. [Epub ahead of print]

Pharmacogenetics and cardiovascular disease--implications for personalized medicine.
Johnson JA, Cavallari LH.
Pharmacol Rev. 2013 May 17;65(3):987-1009.

Identification and Analysis of in vivo VEGF downstream Markers Link VEGF Pathway Activity with Efficacy of Anti-VEGF Therapies.
Brauer MJ, Zhuang G, Schmidt M, et al.
Clin Cancer Res. 2013 May 17. [Epub ahead of print]

Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia.
Yee SW, Mefford JA, Singh N, et al.
J Hum Genet. 2013 May 16. [Epub ahead of print]

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.