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In Print: Last Week's Pharmacogenomics Papers of Note


Circulating microRNA-21 as noninvasive predictive biomarker for response in cancer immunotherapy.
Wang Z, Han J, Cui Y, et al.
Med Hypotheses. 2013 May 10 [Epub ahead of print]

Processed B-Type Natriuretic Peptide Is a Biomarker of Postinterventional Restenosis in Ischemic Heart Disease.
Fujimoto H, Suzuki T, Aizawa K, et al.
Clin Chem. 2013 May 13. [Epub ahead of print]

Challenges and limitations in interpretation of systematic reviews: Making sense of clopidogrel and CYP2C19 pharmacogenetics.
Sorich MJ, Polasek TM, Wiese MD.
Clin Pharmacol Ther. 2013 May 13. [Epub ahead of print]

Platform comparisons for identification of breast cancers with a BRCA-like copy number profile.
Schouten PC, van Dyk E, Braaf LM, et al.
Breast Cancer Res Treat. 2013 May 14. [Epub ahead of print]

Evaluation of Heart Failure Biomarker Tests: A Survey of Statistical Considerations.
De A, Meier K, Tang R, Li M, et al.
J Cardiovasc Transl Res. 2013 May 14. [Epub ahead of print]

Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751.
Innocenti F, Ramírez J, Obel J, et al.
Pharmacogenet Genomics. 2013 May 10. [Epub ahead of print]

Gene-expression differences in peripheral blood between lithium responders and non-responders in the Lithium Treatment-Moderate dose Use Study (LiTMUS).
Beech RD, Leffert JJ, Lin A, et al.
Pharmacogenomics J. 2013 May 14. [Epub ahead of print]

A microarray-based gene expression analysis to identify diagnostic biomarkers for unknown primary cancer.
Kurahashi I, Fujita Y, Arao T, et al.
PLoS One. 2013 May 9;8(5):e63249.

Pharmacogenetics in clinical practice: how far have we come and where are we going?
Johnson JA.
Pharmacogenomics. 2013 May;14(7):835-43.

Lung cancer in never-smokers. Does smoking history matter in the era of molecular diagnostics and targeted therapy?
Ou SH.
J Clin Pathol. 2013 May 9. [Epub ahead of print]

The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer.
Eklöf V, Wikberg ML, Edin S, et al.
Br J Cancer. 2013 May 9. [Epub ahead of print]

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.