Skip to main content
Premium Trial:

Request an Annual Quote

Cepheid Shares Rise Following NEJM Study on TB Test

By a GenomeWeb staff reporter

NEW YORK (GenomeWeb News) – A study appearing in the Sep. 9 issue of the New England Journal of Medicine has reported unprecedented sensitivity and specificity achieved by Cepheid's new molecular tuberculosis test, driving the company's stock up around 9 percent today.

In mid-afternoon trading, Cepheid shares rose to $17.25, following the publication online yesterday of a study in NEJM in which researchers reported that Cepheid's Xpert MTB/RIF test successfully identified 98.2 percent of all cultured-confirmed TB cases, including more than 90 percent of those with smear-negative disease.

In addition, the PCR-based test had a 97.6 percent success rate in detecting patients with resistance to the anti-TB drug rifampin. Test results were achieved in less than two hours.

The test, designed to be used on Cepheid's GeneXpert system, was co-developed with the Foundation for Innovative New Diagnostics and the University of Medicine and Dentistry of New Jersey. The National Institute of Allergy & Infectious Diseases provided additional funding as did the Bill and Melinda Gates Foundation.

In a statement, NIAID said that in 2008 more than 1.8 million people worldwide died from TB. The number of drug-resistance cases is increasing, as well. "New, less costly tools to rapidly diagnose TB and its drug-resistant forms are urgently needed to help stem the tide of new infections," the institute said.

Separately, Cepheid said the test could have particular implications in developing nations in sub-Saharan Africa and Southeast Asia, where TB and HIV are closely linked.

According to David Persing, chief medical and technology officer for Cepheid, "The Xpert MTB/RIF test is the most technologically advanced test for TB ever developed, yet it is simple enough to perform in all corners of the world, including in resource-limited setting where it is most needed."

The test is CE-IVD marked and is expected to become available in the US within the 2012-2013 timeframe, Cepheid said.

More about the NEJM study can be found in GenomeWeb Daily News' sister publication, PCR Insider.

The Scan

Panel Recommends Pfizer-BioNTech Vaccine for Kids

CNN reports that the US Food and Drug Administration advisory panel has voted in favor of authorizing the Pfizer-BioNTech SARS-CoV-2 vaccine for children between 5 and 11 years old.

Sharing How to Make It

Merck had granted a royalty-free license for its COVID-19 treatment to the Medicines Patent Pool, according to the New York Times.

Bring it Back In

Bloomberg reports that a genetic analysis has tied a cluster of melioidosis cases in the US to a now-recalled aromatherapy spray.

Nucleic Acids Research Papers on SomaMutDB, VThunter, SCovid Databases

In Nucleic Acids Research this week: database of somatic mutations in normal tissue, viral receptor-related expression signatures, and more.