Skip to main content
Premium Trial:

Request an Annual Quote

Beckman Coulter Developing NSCLC Companion Dx for Transgene

By a GenomeWeb staff reporter

NEW YORK (GenomeWeb News) – French biopharmaceutical firm Transgene today announced Beckman Coulter will develop a companion diagnostic for Transgene to measure levels of activated Natural Killer (aKN) cells so that patients can be selected for treatment with an immunotherapy candidate for non-small cell lung cancer.

Beckman Coulter will develop the test to measure triple positive — CD16+, CD56+, CD69+/CD45+ lymphocytes — aNK cells to identify patients who may be suitable for treatment with TG4010, an MVA-MUC1-IL2 immunotherapy candidate that is about to enter a Phase IIb/III clinical trial.

Financial and other terms of the agreement were not disclosed.

Transgene said in a statement that findings from the most recent clinical trial indicated TG4010 was well tolerated and extended life expectancy in a subset of patients with a normal level of aNK cells in the blood at baseline.

Separately, Ventana Medical Systems is developing a test for Transgene for the identification of patients with MUC1-positive tumor cells. The test being developed by Beckman Coulter, as well as Ventana's test, will be used in the upcoming clinical trial, which is expected to start recruitment in the middle of the year.

If Transgene is successful in commercializing them, "these companion tests could then serve as a tool for physicians to identify patients who can be treated with TG4010 upon commercialization," the company said.

The company added that it is progressing in discussions with the US Food and Drug Administration's Center for Devices and Radiological health and the agency's Center for Biologics Evaluation and Research regarding the drug.

Transgene has granted Novartis an exclusive worldwide license to develop and commercialize TG4010.

The Scan

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.

Study Highlights Pitfall of Large Gene Panels in Clinical Genomic Analysis

An analysis in Genetics in Medicine finds that as gene panels get larger, there is an increased chance of uncovering benign candidate variants.

Single-Cell Atlas of Drosophila Embryogenesis

A new paper in Science presents a single-cell atlas of fruit fly embryonic development over time.

Phage Cocktail Holds Promise for IBD

Researchers uncovered a combination phage therapy that targets Klebsiella pneumonia strains among individuals experiencing inflammatory bowel disease flare ups, as they report in Cell.