Skip to main content
Premium Trial:

Request an Annual Quote

Abbott to Develop Companion Dx for Epizyme Cancer Drug Candidate

NEW YORK (GenomeWeb News) – Epizyme today said that Abbott will develop a molecular companion diagnostic test for a leukemia drug candidate that the Cambridge, Mass.-based firm is developing.

Abbott will develop a test based on its fluorescence in situ hybridization technology to detect genetic alterations of mixed lineage leukemia, an aggressive subtype of acute myeloid leukemia and acute lymphoblastic leukemia.

Epizyme is developing an inhibitor targeting the DOT1L histone methyltransferase for the treatment of mixed lineage leukemia and will use the Abbott test to detect MLL genetic alterations that lead to the oncogenic function of DOT1L.

Further terms of the alliance were not disclosed.

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.