Skip to main content
Premium Trial:

Request an Annual Quote

20/20 GeneSystems Wins $3M in SBIR Grants

By a GenomeWeb staff reporter

NEW YORK (GenomeWeb News) – 20/20 GeneSystems, a Rockville, Md.-based firm developing companion diagnostics, today said that it has received $3 million in Small Business Innovative Research grants to develop tests to help oncologists predict the effectiveness of targeted cancer therapies.

The grants came from the National Cancer Institute's SBIR program and included a $2.75 million Phase IIB "Bridge Award," and a $200,000 Phase I SBIR contract.

The Bridge Award is directed at development of a companion diagnostic, called PredicTOR, that predicts tumor response to drugs that target, or are impacted by activation of, the mTOR pathway. Drugs included in this class include Pfizer's Torisel (temsirolimus) and Novartis' Afinitor (everolimus), which have been approved for the treatment of kidney cancer.

The Phase I grant supported development of a test to predict kidney tumor response to drugs that target the VEGF pathway, such as Pfizer's Sutent (sunitinib).

Both tests utilize 20/20's Layered-Immunohistochemistry technology, which allows for the simultaneous detection of multiple biomarkers in a single tissue section while preserving its morphology and eliminating several limitations associated with the few current multiplex histology techniques.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.