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$15M Credit Facility Established for MDx Company XDx

NEW YORK (GenomeWeb News) – Oxford Finance today said that it and Silicon Valley Bank have provided a $15 million senior credit facility for molecular diagnostics firm XDx.

The Brisbane, Calif.-based developer of tests for monitoring transplant rejection and autoimmune diseases will use the funds for working capital and for the development of new diagnostic applications using XDx's molecular expression technology.

Along with its AlloMap gene expression test for monitoring heart transplant rejection, launched in 2005 and approved by the US Food and Drug Administration three years later, XDx announced in the spring a deal with Laboratory Corporation of America to develop and commercialize a diagnostic test for systemic lupus erythematosus (SLE).

Also in the company's pipeline are tests directed at the immune system.

In January 2011 XDx established a $12.5 million senior secured loan facility with GE Capital, Healthcare Financial Services.

The Scan

Nucleotide Base Detected on Near-Earth Asteroid

Among other intriguing compounds, researchers find the nucleotide uracil, a component of RNA sequences, in samples collected from the near-Earth asteroid Ryugu, as they report in Nature Communications.

Clinical Trial Participants, Investigators Point to Importance of Clinical Trial Results Reporting in Canadian Study

Public reporting on clinical trial results is crucial, according to qualitative interviews with clinical trial participants, investigators, and organizers from three provinces appearing in BMJ Open.

Old Order Amish Analysis Highlights Autozygosity, Potential Ties to Blood Measures

Researchers in BMC Genomics see larger and more frequent runs-of-homozygosity in Old Order Amish participants, though only regional autozygosity coincided with two blood-based measures.

Suicidal Ideation-Linked Loci Identified Using Million Veteran Program Data

Researchers in PLOS Genetics identify risk variants within and across ancestry groups with a genome-wide association study involving veterans with or without a history of suicidal ideation.