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Critical Path, Hamner Institutes Ink Biomarker Pact

NEW YORK (GenomeWeb News) – Critical Path Institute (C-Path) and The Hamner Institutes for Health Sciences have signed a memorandum of understanding to collaborate on finding markers for monitoring drug-induced liver injury.

The non-profit research organizations plan to collaborate on regulatory science research for predicting, detecting, and monitoring liver safety issues during the development of new medicines. They said a goal of the collaboration is to generate data and reach scientific consensus for biomarkers and other methods that would be submitted to the US Food and Drug Administration to be qualified for specific uses in product development.

"It is imperative that we continue to build important synergies to support cutting-edge research that ultimately translates to getting safer, more effective medicines into the hands of patients," Raymond Woolsey, president and CEO of Tucson, Ariz.-based C-Path.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.