Skip to main content
Premium Trial:

Request an Annual Quote

AstraZeneca, Myriad Expand CDx Collaboration into Lynparza Pancreatic Cancer Study

NEW YORK (GenomeWeb) – Myriad Genetics and AstraZeneca are expanding their agreement to use BRACAnalysis CDx to identify best responders to the PARP inhibitor Lynparza (olaparib) as a metastatic pancreatic cancer treatment.

The two companies have already worked together to bring BRACAnalysis CDx as a US Food and Drug Administration-approved test that identifies germline BRCA mutations in advanced ovarian cancer patients considering treatment with Lynparza. The agency approved the drug in the advanced ovarian cancer setting along with the test in December.

Under their latest agreement, AstraZeneca will use BRACAnalysis CDx to prospectively identify the metastatic pancreatic cancer patients who are likely to respond to Lynparza. Pancreatic cancer patients generally have poor prognosis, with an average life expectancy of three-to-six months after diagnosis. The American Cancer Society estimates that there are 48,000 newly diagnosed pancreatic cancer patients each year in the US, and 40,000 die from the disease annually.

The randomized Phase III study that the BRACAnalysis CDx will be used in will involve 145 pancreatic cancer patients who have not progressed on first-line platinum-based chemotherapy. Patients will be randomized to receive Lynparza 300 mg twice daily or a placebo.

In order to be randomized into the study, patients must have a germline, deleterious BRCA mutation or suspected deleterious BRCA mutation as determined by Myriad's test. Researchers will follow patients for up to four years to assess their progression-free survival, overall survival, a number of other efficacy measures, as well as safety and tolerability of Lynparza. The study started in December and is slated for completion in July 2016.

The Scan

Machine Learning Helps ID Molecular Mechanisms of Pancreatic Islet Beta Cell Subtypes in Type 2 Diabetes

The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

Culture-Based Methods, Shotgun Sequencing Reveal Transmission of Bifidobacterium Strains From Mothers to Infants

In a Nature Communications study, culture-based approaches along with shotgun sequencing give a better picture of the microbial strains transmitted from mothers to infants.

Microbial Communities Can Help Trees Adapt to Changing Climates

Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.