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Glenn Barney, Dario Alessi, Philip Cohen, Stephane Bancel, Noubar Afeyan

Recent collaboration agreements between the company and researchers at the Moffitt Cancer Center and the Buck Institute for Research on Aging will further its "intention of building a portfolio of oncology-related assays using selected-reaction monitoring," said an official.

The work suggests that glycosylation may play a key role in the proteolytic processing of the amyloid precursor protein, implicating it in the generation of Aβ peptide fragments like Aβ1-42 that have been linked to Alzheimer's, said one of the researchers.

The partners will co-develop mass spectrometry-based tests to predict patient response to therapies such as tamoxifen.

The work will focus on the development of mass spec assays for measuring signaling and repair pathway proteins for clinical tumor biopsy analysis.

The cancer center and the applied proteomics company will conduct research to support development of tumor biopsy assays.

The work is part of the European Union's £6.99 million DENAMIC research project, which aims to develop tools for monitoring the neurotoxic effects of environmental pollutants on the cognitive skills and development of children.

For its part in the project called DENAMIC, Proteome Sciences will investigate the effects of neurotoxic chemicals on proteins, peptides, and biochemical pathways in cell models and tissue.

The figure comes from a report commissioned by proteomics firm Proteome Sciences, which, like a number of other protein biomarker firms including Quanterix, Rules-Based Medicine, and NextGen Sciences, has made AD a significant focus of its R&D and commercialization efforts.

Growth initiatives for 2011 include the hiring of additional business development and sales staff, development of assays for cancer and Alzheimer's disease, and expansion of the plexing rates for its TMT reagents.

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Researchers tie a variant in ADAMTS3 to breathing difficulties in dissimilar dog breeds, according to Discover's D-brief blog.

The Japan Times reports that researchers sequenced the genome of a woman who lived during the Jomon period.

Parents of children with rare genetic disease have to contend with shifts in the interpretation of genetic variants, the Wall Street Journal reports.

In Science this week: single-nucleus RNA sequencing of brain tissue from individuals with autism, and more.