Novartis NCCN Publishes First Guidelines for Pediatric Brain Cancer, Recommends Broad NGS Profiling The guidelines recognize the importance of molecular profiling in diagnosing, treating, and identifying clinical trial opportunities for children with high-grade gliomas. Rancho Biosciences Launches Single-Cell Data Science Consortium With Pharma Firms BMS, J&J, Novartis, and Vesalius will work with the bioinformatics firm to develop standards for creating and using single-cell datasets for drug discovery. Precision Cancer Consortium Launches With Bayer, GSK, Roche, Novartis as Founding Members The organization of pharmaceutical and biotechnology firms aims to increase access to genomic testing for cancer patients. Breast Cancer Study Shows Number of Mutated PIK3CA Alleles Affects Tumor Aggressiveness Studies in breast tumors revealed a "biphasic" relationship between mutant PIK3CA allele dosage and stem cell-like features as well as aggressiveness. FDA Approves Foundation Medicine's Liquid Biopsy Test as CDx for Novartis' Tabrecta in NSCLC The blood-based test is the second Foundation Medicine assay approved to ID patients eligible for the drug due to mutations leading to MET exon 14 skipping. Feb 16, 2021 Circulating Tumor DNA Provides Prognostic Clues in Advanced BRAF-Mutated Melanoma Cases Jan 14, 2021 Invitae, Pharma Firms Partner to Develop Standard MRD Panel for AML Clinical Trials Dec 9, 2020 Nonprofit Friends of Cancer Research Launches Public-Private HRD Harmonization Project Oct 27, 2020 FDA Approves Foundation Medicine Liquid Biopsy Test as CDx for Three Targeted Therapies May 6, 2020 FDA Approves Novartis' Capmatinib, Foundation Medicine CDx for Metastatic NSCLC Dec 4, 2019 FDA Approves Foundation Medicine CDx for Novartis Breast Cancer Drug Piqray Nov 19, 2019 Double Mutations in PIK3CA Gene Increase Patient Sensitivity to Targeted Therapies, Study Finds Premium Nov 7, 2019 Colorectal Cancers Dial up Mutability in Response to Targeted Treatments Oct 21, 2019 SomaLogic Expands Agreement With Novartis Sep 23, 2019 Global Survey Reveals Suboptimal Molecular Testing Access in Lung Cancer Despite Broad Guidelines Premium Jun 18, 2019 Next-Generation Sequencing of Pediatric Cancer Patients Could Transform Treatment Paradigms Premium May 24, 2019 FDA Approves Qiagen's PIK3CA Test as Companion Test for Novartis Breast Cancer Drug Feb 14, 2019 AbCellera, Novartis Partner on Antibody Drug Discovery Dec 7, 2018 Novartis Drug Shows Promise in PIK3CA Mutated Breast Cancer, Potential Utility of ctDNA Testing Premium Dec 6, 2018 Qiagen to Develop Companion Dx for Novartis Breast Cancer Drug Nov 13, 2018 Health Canada Approves Two BCR-ABL Tests Oct 30, 2018 Precision Oncology Highlights From ESMO 2018 Oct 17, 2018 Foundation Medicine, Novartis Partner to Develop CDx for Oncology Drugs Aug 1, 2018 New Lung Cell Type Linked to Cystic Fibrosis Emerges From Mouse, Human Cell Atlas Studies Jun 4, 2018 MolecularMD, Genoptix Ink Marketing Agreement for CDx to Novartis CML Drug Load More Breaking News Simple HealthKit Raises $8M in Series A Round Top Five Articles on GenomeWeb Last Week: Quantum-Si Layoffs, UBS Coverage Initiations, More LumiraDx Secures FDA Emergency Use Authorization, UK Approval for COVID-19, Flu Test Rarity Bioscience Raises Additional €500,000 Cancer Prognoses Informed by Module-Based Approach, Study Finds The Scan UK Team Presents Genetic, Epigenetic Sequencing Method Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers. DNA Biobank Developed for French Kidney Donors, Recipients The KiT-GENIE biobank described in the European Journal of Human Genetics contains DNA samples, genotyping profiles, immune patterns, and clinical features for thousands of kidney donors or transplant recipients in Nantes, France. Cardiometabolic Disease May Have Distinct Associations With Microbial Metabolites in Blood, Gut By analyzing gut microbes in combination with related metabolites in feces and blood, researchers in Nature Communications found distinct cardiometabolic disease relationships at each site. Study Reveals New Details About Genetics of Major Cause of Female Infertility Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.