Merck Illumina, Merck Partner to Advance Homologous Recombination Deficiency CDx, Research Assay Under the terms of the deal, Illumina will develop a new HRD CDx for the EU and UK markets and a research-use only HRD assay that will be add-on content for its TSO 500 panel. Integrated Tumor, Microbiome Features Influence Immunotherapy Combo Effects in Advanced Melanoma Gut microbiome features showed ties to treatment response and immune-related adverse events in advanced melanoma patients on a combined checkpoint blockade treatment. Lynparza Benefit in Early BRCA-Mutated Breast Cancer Reignites Universal Genetic Testing Discussion Premium The OlympiA trial showed a disease-free survival benefit with adjuvant PARP inhibitor therapy for early-stage, BRCA1/2-mutated, HER2-negative breast cancer patients. M2Gen Lands New Private Investment, Inks Research Deal with Merck Bioinformatics firm M2Gen will provide Merck with deidentified clinical and genomics data to aid in oncology drug discovery and development. MSK Study Underscores Need to Validate Cancer-Specific Tumor Mutational Burden Cutoffs Premium A TMB-high cutoff of 10 mutations per megabase doesn't predict immunotherapy responses universally well across cancer types, according to a paper published in JAMA Oncology. Jan 11, 2021 Illumina CEO Discusses Pan-Cancer IVD Assay, CDx Collaborations at JP Morgan Dec 9, 2020 Nonprofit Friends of Cancer Research Launches Public-Private HRD Harmonization Project Nov 13, 2020 FDA Approves Merck's Keytruda, Agilent CDx in PD-L1-High Triple-Negative Breast Cancer Nov 9, 2020 FDA Approves Foundation Medicine Liquid Biopsy Test as CDx for Lynparza Jul 24, 2020 TMB Harmonization Effort Yields Calibration Method to Correct Inter-Assay Variation Premium Jun 18, 2020 Promega Maintains Microsatellite Instability IVD Plans Amid Evolving Cancer Test Landscape Premium Jun 17, 2020 FDA Approves Merck's Keytruda, Foundation Medicine CDx for TMB-High Solid Tumors May 20, 2020 FDA Approves Lynparza With Myriad, Foundation Med CDx Tests in HRR-Mutated Prostate Cancer May 11, 2020 FDA Approves Lynparza/Avastin With Myriad Genetics CDx for Platinum-Sensitive Ovarian Cancer Apr 27, 2020 Merck, ISB Collaborating on COVID-19 Drug, Vaccine Target Discovery Apr 14, 2020 Merck Bid for Second Pan-Cancer Keytruda Indication Would Raise Tumor Mutation Burden to CDx Status Premium Mar 30, 2020 Myriad Genetics Seeks Japan Approval for Advanced Pancreatic, Prostate Cancer Companion Diagnostic Mar 5, 2020 Genedata Moves Into R&D for Nonprofits, Adds Digital Pathology Support Premium Feb 11, 2020 Myriad Files sPMA With FDA for Test to ID Best Responders to Lynparza, Avastin Combination Jan 21, 2020 Myriad Genetics Files for FDA Approval of BRACAnalysis CDx for Lynparza in Prostate Cancer Dec 30, 2019 FDA Approves AstraZeneca's Lynparza, Myriad Genetics' CDx for BRCA-Positive Pancreatic Cancer Dec 12, 2019 Immunotherapy Regimens Yield Contrasting Results in Early Triple Negative Breast Cancer Premium Dec 4, 2019 PGDx Gets IDE For Tissue NGS Test in Merck Immunotherapy Trial Nov 6, 2019 Merck, Promega Collaborate to Develop MSI CDx for Keytruda Aug 7, 2019 Myriad Genetics Seeking Additional FDA Approval for BRACAnalysis CDx Load More Breaking News In Brief This Week: Illumina, Personalis, Proteomedix, and More Ancient DNA Details Population Dynamics Within Andean Tiwanaku Civilization Genomic Data Spanning 2K Years Gives Glimpse of Etruscan Origins, Population Changes People in the News: New Appointments at Hologic, Akoya Biosciences, Caris Life Sciences, More At NSGC, Genetic Counselors Address Race-Based Medicine, Ways to Change New Products Posted to GenomeWeb: Becton Dickinson, Cosmos-ID, OncoDNA, More The Scan US Booster Eligibility Decision The US CDC director recommends that people at high risk of developing COVID-19 due to their jobs also be eligible for COVID-19 boosters, in addition to those 65 years old and older or with underlying medical conditions. Arizona Bill Before Judge The Arizona Daily Star reports that a judge is weighing whether a new Arizona law restricting abortion due to genetic conditions is a ban or a restriction. Additional Genes Wales is rolling out new genetic testing service for cancer patients, according to BBC News. Science Papers Examine State of Human Genomic Research, Single-Cell Protein Quantification In Science this week: a number of editorials and policy reports discuss advances in human genomic research, and more.