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Executives at two commercial payors said they'd follow CMS' lead when it comes to patients covered under Medicare but beyond that their support for the agency's policy is less clear. 

The stool-based test was approved by US regulators in 2014 and included as an A-rated service in the US Preventive Services Task Force's colorectal cancer screening guidelines earlier this year.

The deal suggests the company is making steady progress toward its goal of signing coverage deals with all major private payors by year end.

The case suggests that the Affordable Care Act's provisions on coverage of preventive services may add another layer of complexity to already strained relations.

The company estimates Humana owes it upwards of $800,000 in payment for nearly 4,700 Cologuard tests it has performed since October 2014.

This article has been updated to clarify that Genomic Health has submitted research data on Oncotype DX testing in the DCIS population to the San Antonio Breast Cancer Symposium. The abstract has not yet been accepted for presentation. Originally published Aug. 5.

The contract will expand coverage for MammaPrint by more than 17 million lives, according to Agendia.

Already a pioneer in incorporating pharmacogenetic testing into its PBM programs, Medco's decision to buy DNA Direct signals its intent to be a "one-stop shop" for payors and employers interested in using genetically guided medicine to make healthcare more efficient and lower costs.

Data from two national insurers, Humana and Aetna, shows that around 20 percent of requests for the test do not meet requirements for testing under their policy. A United Healthcare official has cited competitors' data suggesting that as much as 80 percent of requests for Myriad's BRCA test are withdrawn after pre-certification and genetic counseling procedures are conducted.

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Jonathan Lord, Lisa Wise, James O'Leary, Paul Keim

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Bloomberg reports that the DNA-for-cash deal reported in Kentucky might be a more widespread scam.

St. Jude Children's Research Hospital scientists have treated infants with X-linked severe combined immunodeficiency using gene therapy in an early phase study.

St. Louis Public Radio reports that some African Americans are turning to DNA ancestry testing to help guide genealogical searches.

In Nature this week: a genomic analysis of the snailfish Pseudoliparis swirei, ancient DNA analysis gives insight into the introduction of farming to England, and more.