Gradalis

The drug combines an RNAi payload with an agent designed to stimulate a patient's immune system against their tumors.

Title: Nucleic Acid Microparticles for Pulmonary Delivery
Patent Number: 8,808,747
Filed: April 17, 2008

Key RNAi Drugs in the Clinic

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NEW YORK (GenomeWeb) – With more interest from industry and investors than ever before, the RNAi therapeutics field has a record number of drug candidates in human testing for indications ranging from viral disease to cancer to skin disorders.

Gradalis has promoted Phillip Maples as executive vice president and chief technical officer.

Following the close of Dicerna Pharmaceuticals Series C round of financing last week, the RNAi therapeutics space has seen a dramatic increase in investor interest, with privately held companies in the field pulling in more than $100 million thus far in 2013.

Gradalis has named Joseph Limber as its president and CEO, replacing David Shanahan, who was a co-founder of the company.

Gradalis this week announced interim data from a phase II trial of its personalized cancer vaccine, dubbed FANG, showing that the therapy elicits an immune response and delays time to disease recurrence in advanced-stage ovarian patients by more than a year compared with those re

Gradalis announced this week that it has closed a $24 million Series B round of financing.

Two years after the US Patent and Trademark Office reinstated its core patent, Australia's Benitec Biopharma has once again set its sights on finding licensees for its expressed RNAi intellectual property.

With its core expressed RNAi technology under evaluation in several phase I and II cancer studies, Gradalis is setting its sights on transitioning from a company focused on a handful of drug candidates into one with a platform technology that can be partnered out to others workin

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Customers might want to consider what they might learn about their risk of diseases like Alzheimer's before snagging the genetic testing kits that are on many gift guides this year, NJ.com writes.

The Wall Street Journal reports there is uncertainty surrounding whether He Jiankui's embryo editing did what he said it did.

Stat News reports that the pause on procuring fetal tissue for intramural US National Institutes of Health research will soon affect additional labs there.

In Nature this week: genomic analysis of the invasive fall webworm, amp of constrained coding regions within the human genome, and more.