BioTrove

Scientists from Hungarian pharmaceutical development firm Avidin and the Hungarian Academy of Sciences have combined digital PCR on Life Tech's OpenArray platform with patch-clamp recording to enable exact quantification of gene expression and correlate it to phenotypic data in i

Movers & Shakers

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Albert Fornace, Amrita Cheema, Dilek Mir, Gregory Critchfield

Life Tech also disclosed that the laboratory of Victor Ambros at the University of Massachusetts Medical School and affiliated RNAi Therapeutics Institute is an early-access customer of the product.

Startups QuantaLife and Inostics join more established outfits RainDance Technologies and Life Technologies in exploring the digital PCR market, but all players will need to negotiate what is sure to be a complex intellectual property landscape.

Digital PCR may be on the verge of becoming nearly as ubiquitous as its predecessor, quantitative real-time PCR, thanks to the integration of empowering nanoscale and microfluidic technologies.

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Albert Luderer

The shelf registration is tied to Life Technologies' acquisition late last year of BioTrove.

Life Tech's Applied Biosystems subsidiary previously offered gene-expression and genotyping assays preloaded on microtiter plates or on 384-well microfluidics cards, but prior to the BioTrove acquisition, customers were not able to get most of that content in a higher-throughput format.

Biocius holds all of the intellectual property related to the RapidFire mass spectrometry platform formerly owned by Biotrove.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.