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As part of an international effort to sequence 10,000 vertebrate genomes, researchers at BGI are getting ready to sequence 100 vertebrate species over the next year or two.

The new sequence data includes 156 new insertions corresponding to novel exons and noncoding regions. The researchers also compared their data to a next-generation sequence and de novo assembled genome, highlighting the advantages and limitations of the newer technology.

BGI will use Agilent's SureSelect solution-based target enrichment product, the Bravo automated liquid-handling platform, and the 2100 Bioanalyzer.

The study, which besides BGI involves researchers at the University of Florida and at the University of Maryland at College Park, is part of BGI's recently launched project to sequence 1,000 plant and animal reference genomes over the next two years.

Chinese and American researchers plan to sequence and compare the genomes of the sea slug, Elysia chlorotica, and Vaucheria litorea, an algal species from which the slug has taken chloroplast biosynthesis genes.

The sequencing was done at BGI-Shenzen and marked the first step in the four-year MetaHIT project, which aims to create a comprehensive gene catalog of the gut microbiome in order to understand how the bacteria that live in human intestines are related to disease.

Researchers from BGI Shenzhen and elsewhere used a metagenomics approach to identify and characterize the microbial genes found in the human gut.

The team used an assortment of sequencing technology, including 454 GS FLX Titanium, SOLiD, and Illumina, and de novo assembled one genome from 454 sequence data. An analysis comparing results from the three platforms is in preparation.

The project, announced just before the start of the Chinese year of the tiger last weekend, is part of BGI's goal to sequence the genomes of 1,000 plant and animal reference species over the next two years.

A University of Copenhagen-led team reported today that they have sequenced a draft version of an ancient human genome from the remains of a man who lived in Greenland some 4,000 years ago.


A UK woman is suing three National Health Service Trusts for not telling her about her father's Huntington's disease diagnosis, the BBC reports.

LiveScience reports that a novel mutation in the LPL gene was uncovered in three siblings with very high triglyceride levels.

The president of Nankai University is embroiled in a data manipulation scandal, the South China Morning Post reports.

In PNAS this week: cytotoxic CD4 T cell signature in supercentenarians, evolutionary history of beetles, and more.