Affomix

In a recent interview with ProteoMonitor, Swiss Federal Institute of Technology Zurich researcher Ruedi Aebersold observed that to a significant extent, proteomics has been constrained by a lack of good affinity reagents (

Anticipating that NGS will become a key clinical tool in coming years, several proteomics firms and researchers are investigating it as a platform for protein biomarker detection assays that use nucleotides as capture agents, hoping to take advantage of the technology's precision and multiplexing ability.

Funding Update

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New NIH Grants for Sequencing-Related Technology and Methods, January-June 2010

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John Boyce, James Slattery, Sam Raees

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David Weitz, John Boyce

The company will be using its automated, high-throughput monoclonal antibody selection technology to produce several antibodies for each protein target chosen by PGx Centre researchers, enabling them to undertake quantitative, multiplexed profiling of the putative biomarkers.

Affomix and the PGx Centre will develop reagents for the quantitative multiplex profiling of candidate biomarkers that may allow clinicians to predict and evaluate how patients respond to novel anti-atherosclerotic agents.

Affomix will supply City of Hope with monoclonal antibodies that will be used to create proteomic profiles that are characteristic of a number of cancers such as renal and prostate cancers.

City of Hope will then use Affomix's recombinant antibodies to generate proteomic profiles characteristic of a number of cancers, such as renal and prostate.

Affomix will use its Y2HExpress technology to select antibodies for Kalgene with potential diagnostic and therapeutic use in breast cancer.

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Jay Shendure and his colleagues have developed a new method to more comprehensively identify human cell types, the NY Times reports.

Researchers in the UK and Japan have shown that infertility in mice with three sex chromosomes can be overcome, according to the Guardian.

China is embracing preimplantation genetic diagnosis, Nature News reports. 

In PLOS this week: host genetic factors associated with cervical neoplasia progression, population patterns for an ancient flowering rainforest plant, and more.