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In Brief This Week: Epigenomics; Chronix Biomedical; Source Bioscience, Illumina; Genewiz; CambridgeSoft, VIB; Isilon Systems, TGen; and More

By a GenomeWeb staff reporter

NEW YORK (GenomeWeb News) – Epigenomics said this week that updated study data on its Septin9 biomarker had detected colorectal cancer cases with a sensitivity of 63 percent and specificity of around 89 percent. The German molecular diagnostics firm said that the results meet the targeted specificity range of 85 percent to 90 percent, which should support public and private payer coverage and reimbursement. The results met the firm's primary study objective.

Chronix Biomedical this week said that a study published in the current online edition of Molecular Cancer Research showed that the firm's method of detecting invasive breast cancer using circulating DNA had a specificity level of 95 percent and sensitivity of 90 percent.

"The promising diagnostic sensitivity and specificity achieved in this study further confirm the value of circulating DNA for disease detection and suggest that laboratory tests using this approach may have the potential both to screen large populations for cancer before symptoms appear and to monitor patients for the recurrence of cancer once treated," William Mitchell, professor of pathology at Vanderbilt University School of Medicine and a co-author of the study, said in a statement.

Source BioScience said this week that it is the first UK lab customer to purchase Illumina's new HiSeq 2000 high-throughput, next-generation sequencing platform. Source BioScience said it is the UK's only Illumina CSPro certified sequencing lab.

Genewiz has added gene synthesis to its services offerings. The firm said that it can synthesize genes of varying complexities with extremely high success rates, spanning short genes to long, 50-kb genes and difficult genes with repetitive sequences, high GC-content, or secondary structures.

Belgian non-profit institute VIB has chosen CambridgeSoft's E-Notebook for capturing and sharing data across its biotechnology domains, including genomics, plant biology, neurobiology, and microbiology.

Isilon Systems this week said that the Translational Genomics Research Institute is using the firm's Isilon IQ scale-out NAS as the primary storage solution for the institute's genome sequencing research.

Sample prep technologies firm Microchip Biotechnologies has changed its name to IntegenX.

Dotmatics has licensed its informatics suite to Heptares Therapeutics. The suit covers SAR analysis, chemical informatics, data capture, knowledge management compound sourcing and business intelligence solutions.

The Scan

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.

Clinical Genomic Lab Survey Looks at Workforce Needs

Investigators use a survey approach in Genetics in Medicine Open to assess technologist applications, retention, and workforce gaps at molecular genetics and clinical cytogenetics labs in the US.

Study Considers Gene Regulatory Features Available by Sequence-Based Modeling

Investigators in Genome Biology set sequence-based models against observational and perturbation assay data, finding distal enhancer models lag behind promoter predictions.

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.