Clinical Sequencing | GenomeWeb

Clinical Sequencing

A 400-sample retrospective analysis in invasive breast cancer will inform a basket trial that the Ontario Institute for Cancer Research hopes to soon launch.

Harvard researchers found that variants previously classified as pathogenic were in fact benign, disproportionately affecting patients of African ancestry. 

The technique will use optical maps and barcodes in order to generate long scaffolds from short-read sequencing technology.

The Sydney-based genomics center is implementing diagnostic sequencing pipelines and figuring out best practices for incorporating genomics into healthcare.

The study adds to a growing body of evidence suggesting that expanded carrier screening tests can better identify at-risk couples. 

Method of sequencing nucleic acid colonies formed on a surface by re-seeding
Delaying real-time sequencing
Alternative nucleotide flows in sequencing-by-synthesis methods
Nucleic acid amplification
Method of determining RNA integrity
Methods and systems for processing polynucleotides

In PNAS this week: chromosome instability in S. cerevisiae, structural differences and sequence divergence in rice, and more.

The San Diego Union-Tribune takes a look at the work to be done in personalized medicine.

An op-ed in the Wall Street Journal calls for the establishment of a patent court staffed by judges and experts with science backgrounds.

In PLOS this week: variants that affect COPD biomarkers, high genetic diversity of Cryptococcus gattii in Brazil, and more.