New Data on CYP2C19 Loss-of-Function Alleles Questions Impact of Plavix PGx Testing | GenomeWeb

By Turna Ray

CYP2C19 alleles ⢀ which various studies have shown to limit response to the anti-platelet drug Plavix in carriers of the polymorphisms ⢀ did not have the same impact on patients' ability to metabolize the drug in a study published in the New England Journal of Medicine last week.

The authors of the study said they believe the data raises doubts on the clinical utility of genotyping for CYP2C19 loss-of-function alleles as a way to direct Plavix therapy in patients with acute coronary syndrome and atrial fibrillation.

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