By Turna Ray

University of Maryland researchers have confirmed in a genome-wide association study that the CYP2C19*2 polymorphism plays a "major role" in how patients respond to the anti-clotting drug Plavix (clopidogrel).

The researchers now plan to conduct a prospective, randomized-controlled trial and form a pharmacogenomics consortium specifically focused on validating and discovering new gene-response variants for the drug.

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