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New Products: Oct 18, 2011

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GenBank release 186.0 is available here via FTP from the National Center for Biotechnology Information. It contains data as of Oct. 13, 2011.

The new release comprises approximately 132 gigabases of data from 144 million entries of non-whole genome sequencing, non-CON sequences, and around 219 gigabases from 68 million entries from whole-genome sequences. Uncompressed, the release 185.0 flatfiles require around 518 gigabases.

Since the previous release in August, the non-WGS/non-CON portion grew by 1.4 gigabases, increasing the number of entries by 2.2 million. An additional 789,185 records were updated.


NCBI has also released build 135 of dbSNP, available here. The release is based on the NCBI genome build GRCh37.3 that included assembly changes and also includes new submissions from phase I of the 1000 Genomes Project.


Life Technologies has launched a series of products for its Ion Torrent PGM (see story, this issue). The Ion Xpress Plus Fragment Library Kit reduces library prep from four hour to two hours. The Torrent Suite 1.5 is a suite of new algorithms that increases base output by 100 percent and the number of perfect 100-base-pair reads by more than 200 percent, according to the company. Additionally, the software reduces analysis time to 30 minutes on the 314 chip and to one hour on the 316 chip.

The company also launched the Ion TargetSeq Custom Enrichment kit, an in-solution hybridization kit to enrich targets greater than 100 kilobases; and the Ion Xpress DNA Barcode Adaptor 1-16 kit, a 16 barcode kit, which has the potential to scale up to 384 barcodes.

The Scan

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.

DNA Biobank Developed for French Kidney Donors, Recipients

The KiT-GENIE biobank described in the European Journal of Human Genetics contains DNA samples, genotyping profiles, immune patterns, and clinical features for thousands of kidney donors or transplant recipients in Nantes, France.

Cardiometabolic Disease May Have Distinct Associations With Microbial Metabolites in Blood, Gut

By analyzing gut microbes in combination with related metabolites in feces and blood, researchers in Nature Communications found distinct cardiometabolic disease relationships at each site.

Study Reveals New Details About Genetics of Major Cause of Female Infertility

Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.