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New Products: Oct 26, 2010


Life Technologies has released its Exact Call Chemistry probe to increase the accuracy of sequencing on its SOLiD sequencers. According to the company, the ECC probe has demonstrated greater than 99.99 percent average single-read accuracy. The concept was first detailed in March, and originally called 2+1 (IS 3/9/2010).

Caliper Life Sciences has released a higher sensitivity DNA assay for its LabChip GX analytical platform and the new Sciclone NGS Workstation. The LabChip GX assay is designed to help in quality control steps that assess concentration and size distribution of next-generation sequencing libraries using microfluidics technology. The Sciclone NGS Workstation automates sample-prep steps such as adapter ligation, exome capture, PCR setup, and nucleic acid cleanup.

Adaptive TCR has launched its immunoSEQ product line, including its immunoSEQ profiling service and immunoSEQ Analyzer bioinformatics software platform.

According to the company, the immunoSEQ assays use proprietary chemistry to amplify rearranged CDR3 regions of T-cell receptor genes, generating millions of cell-specific sequences. The immunoSEQ Analyzer is a software suite that allows researchers to analyze the data from the assays.

Golden Helix
will incorporate video graphics cards to run its next version of its SNP and Variation Suite software, which it will release in November. The use of GPUs reduces the time of genetic analysis, according to the company. It is first using the GPUs to improve its copy number variation detection method.

GenBank release 180.0 is available here via FTP from the National Center for Biotechnology Information. It contains data as of Oct. 15. The new release comprises approximately 119 gigabases and 126 million entries from non-WGS, non-CON sequences, and 175 gigabases and 59 million entries from WGS sequences.

Uncompressed, release 180.0 flat files require roughly 457 gigabytes for sequence files only. The ASN.1 data require approximately 375 gigabytes.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.