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New Products: Oct 27, 2009

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RainDance Technologies has added methyl-seq and ultra-deep resequencing applications for its RDT 1000 sequence enrichment platform.

Methyl-seq enables the targeted amplification of bisulfite-converted DNA for the sequence-based detection of methylated DNA. Ultra-deep resequencing allows users to characterize rare variants in highly heterogeneous samples, such as those found in cancer tumors. Standard PCR approaches have been difficult to use for this application, according to the company, because of the loss of accurate DNA representation.

Both applications will be commercially available during the first half of 2010.


Life Technologies' Applied Biosystems has made the 3500 Series Genetic Analyzer, a capillary electrophoresis sequencing system, globally available. The instrument enables researchers to run up to 1,100 sequencing or 1,200 genotyping samples per day.

The release follows an early-access program that started in May (see In Sequence 5/26/2009) and included the Peter MacCallum Cancer Centre in Australia, Massachusetts General Hospital, the Institute Paoli Calmette in France, University College London Hospital, Silvestrini Hospital Molecular in Italy, Laboratório de Genômica e Biologia Molecular, Centro de Pesquisa – Hospital A. C. Camargo in Brazil, the Transcriptome Research Group of the National Institute of Radiological Sciences in Japan, and the University of Tokyo.

The Scan

And Back

The New York Times reports that missing SARS-CoV-2 genome sequences are back in a different database.

Lacks Family Hires Attorney

A lawyer for the family of Henrietta Lacks plans to seek compensation from pharmaceutical companies that have used her cancer cells in product development, the Baltimore Sun reports.

For the Unknown

The Associated Press reports that family members are calling on the US military to use new DNA analysis techniques to identify unknown sailors and Marines who were on the USS Arizona.

PLOS Papers on Congenital Heart Disease, COVID-19 Infection Host MicroRNAs, Multiple Malformation Mutations

In PLOS this week: new genes linked to congenital heart disease, microRNAs with altered expression in COVID-19, and more.