RainDance Technologies has added methyl-seq and ultra-deep resequencing applications for its RDT 1000 sequence enrichment platform.
Methyl-seq enables the targeted amplification of bisulfite-converted DNA for the sequence-based detection of methylated DNA. Ultra-deep resequencing allows users to characterize rare variants in highly heterogeneous samples, such as those found in cancer tumors. Standard PCR approaches have been difficult to use for this application, according to the company, because of the loss of accurate DNA representation.
Both applications will be commercially available during the first half of 2010.
Life Technologies' Applied Biosystems has made the 3500 Series Genetic Analyzer, a capillary electrophoresis sequencing system, globally available. The instrument enables researchers to run up to 1,100 sequencing or 1,200 genotyping samples per day.
The release follows an early-access program that started in May (see In Sequence 5/26/2009) and included the Peter MacCallum Cancer Centre in Australia, Massachusetts General Hospital, the Institute Paoli Calmette in France, University College London Hospital, Silvestrini Hospital Molecular in Italy, Laboratório de Genômica e Biologia Molecular, Centro de Pesquisa – Hospital A. C. Camargo in Brazil, the Transcriptome Research Group of the National Institute of Radiological Sciences in Japan, and the University of Tokyo.