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EdgeBio, Life Tech to Use SOLiD Methylation Sequencing for Large-Scale VCU Schizophrenia Study


Life Technologies and EdgeBio said this week that they are partnering with researchers at Virginia Commonwealth University on a large-scale sequencing study of schizophrenia.

The study, which involves a cohort of 1,500 patients and controls, is using a whole-genome approach to find methylation patterns associated with schizophrenia.

For the project, scientists at EdgeBio will use Life Tech's MethylMiner Methylated DNA Enrichment kit to selectively enrich methylated DNA from the 1,500 samples and sequence it on the SOLiD system, along with 75 technical replicates. VCU researchers will analyze the data and plan to study the most promising markers further in an additional 1,600 patients and controls.

According to the partners, the study represents the first large-scale genome-wide sequencing study to detect epigenetic markers in order to understand the causes of a complex disease.

The Scan

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.

Science Papers Describe Approach to Predict Chemotherapeutic Response, Role of Transcriptional Noise

In Science this week: neural network to predict chemotherapeutic response in cancer patients, and more.