Complete Genomics has sequenced the whole genomes of 600 individuals from 20 Mexican-American families from San Antonio to try and identify variants involved in type 2 diabetes.
The project is being done as part of the Type 2 Diabetes Genetic Exploration by Next-Generation Sequencing in Multi-Ethnic Samples, or T2D-GENES, consortium, and is funded by the National Institute of Diabetes and Digestive and Kidney Diseases.
Researchers from the Texas Biomedical Research Institute have been collecting healthcare data from 2,500 individuals from 85 Mexican-American families since 1991. The 600 selected for whole-genome sequencing had been previously genotyped in an earlier genome-wide association study and come from families with increased prevalence of diabetes.
Complete Genomics said that it sequenced the genomes of the 600 individuals to greater than 50-fold coverage. Researchers plan to use the sequence data to complement the GWAS data to find both common and rare genetic variant, which could help reveal subtypes of the disease, identify novel therapeutic targets, and find variants associated with disease risk.
"Our aim is to identify genetic variants that play a role in type 2 diabetes risk or influence variability in diabetes-related traits, such as blood glucose levels and body mass index," John Blangero, a geneticist at the Texas Biomedical Research Institute and one of the project's researchers, said in a statement.