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Baylor's Human Genome Sequencing Center to Add More SOLiDs, At Least Triple Sequencing Output

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By Julia Karow

Life Technologies said this week that Baylor College of Medicine's Human Genome Sequencing Center will add several Applied Biosystems SOLiD sequencers to its existing fleet, bringing the total number to 20.

As of this spring, the center had eight SOLiD sequencers, 10 Roche/454 GS FLX machines, and two Illumina Genome Analyzers installed.

With the additional SOLiD machines, and an increase in the platform's throughput, the center expects to at least triple its current sequence production.

Baylor plans to use its SOLiDs to analyze human genomes and to detect genetic changes occurring in cancer, autism, and cardiovascular disease.

Baylor's HGSC is one of three centers providing sequencing for the Cancer Genome Atlas, which received $275 million in new funding, including $175 million in Recovery Act funds, last week (see related story in this issue).

The center is also contributing sequencing data to a multi-center project to study the genetic structure of autism that recently received $8 million in stimulus funding from the National Institute of Mental Health (see related story in this issue).

"In order to unravel the complexities of genomic disease, we need highly accurate, cost-effective and ultra-high-throughput sequencing technology," said HGSC Director Richard Gibbs in a statement. "Our experience with SOLiD demonstrates that the industry-leading accuracy and throughput is ideal for the in-depth analysis of complex genomes."

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