Two Research Teams Tie Methylation Changes in the Brain to Alzheimer's Disease Developments | GenomeWeb

NEW YORK (GenomeWeb) – A pair of studies appearing in Nature Neuroscience yesterday uncovered epigenetic changes associated with the development of Alzheimer's disease.

For the studies, the two research teams conducted epigenome-wide association studies to search for DNA regions that were differentially methylated in people who had Alzheimer's disease as compared to those without the disease. While the researchers uncovered nearly a dozen differentially methylated regions, both groups homed in on a hypermethylated region at the ANK1 gene.

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