Originally published Nov. 22.

Doctors have been in a "should we or shouldn't we" conundrum with warfarin pharmacogenetic testing for years.

The US Food and Drug Administration has updated the label for the widely used anticoagulant twice, in 2007 and 2010, informing doctors that patients with certain variants of CYP2C9 and VKORC1 genes may require non-standard warfarin doses when they start therapy. Meanwhile, physician practice guidelines don't recommend genotyping patients ahead of prescribing them warfarin.

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