Skip to main content
Premium Trial:

Request an Annual Quote

TGen, Barrow, Nemucore Receive $3M for Personalized Glioblastoma Treatment Research

NEW YORK (GenomeWeb News) – The Translational Genomics Research Institute and its partners Nemucore Medical Innovations and Barrow Neurological Institute at St. Joseph's Hospital and Medical Center have received a $3 million grant to fund a personalized glioblastoma treatment study.

TGen said yesterday that the funding from the Ben & Catherine Ivy Foundation will support a trial using individual tumor genetics to optimize targeted glioblastoma therapies that will be delivered via nanotechnology tools.

The project will harness TGen's genome sequencing and molecular profiling capabilities and Nemucore's nanomedicines, which are designed to deliver medications by evading cancer defenses.

Barrow, which treats one of the highest volumes of brain tumor patients in the US, will conduct preclinical work for the nanomedicines and host the clinical trials, TGen said.

Nemucore will work with the research partners from the beginning of the study, which will enable the company to advise the team on methods and components as it develops formulations for crossing the blood-brain barrier, according to company CEO Tim Coleman.

"Without this type of integrated approach it would take much longer to translate these individualized investigational therapies to the clinic," Coleman said in a statement.

The research team also plans to work with Peoria, Ariz.-based Blue Ocean Manufacturing, where Coleman is also CEO, to develop methods to manufacture the resulting personalized medication.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.