Researchers Use APOE-TOMM40 Haplotypes to Explain African-Americans' Unique Alzheimer's Risk Profile | GenomeWeb

NEW YORK (GenomeWeb) – Using a new in-phase assay, researchers led by Duke University's Allen Roses believe they have captured key differences in APOE and TOMM40 haplotypes between African-American, Caucasian, and West African populations. The varying APOE and TOMM40 haplotypes in these populations may explain why African-Americans, despite harboring lower frequencies of the APOE4 risk allele compared to Caucasians, have similar rates of Alzheimer's disease.

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