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In Print: Recent Pharmacogenomics Papers of Note: Aug 21, 2013


Graft-versus-host disease biomarkers: omics and personalized medicine.
Paczesny S, Raiker N, Brooks S, Mumaw C.
Int J Hematol. 2013 Aug 20. [Epub ahead of print]

Immunohistochemistry reliably detects ALK rearrangements in patients with advanced non-small-cell lung cancer.
Han XH, Zhang NN, Ma L, et al.
Virchows Arch. 2013 Aug 18. [Epub ahead of print]

Targeted therapy; from advanced melanoma to the adjuvant setting.
Ahn A, Eccles MR.
Front Oncol. 2013 Aug 9;3:205.

Factors influencing organizational adoption and implementation of clinical genetic services.
Hamilton AB, Oishi S, Yano EM, et al.
Genet Med. 2013 Aug 15 [Epub ahead of print]

Cost-effectiveness of the 21-gene assay for guiding adjuvant chemotherapy decisions in early breast cancer.
Paulden M, Franek J, Pham B, et al.
Value Health. 2013 Jul-Aug;16(5):729-39.

Potential of Dihydropyrimidine Dehydrogenase Genotypes in Personalizing 5-Fluorouracil Therapy Among Colorectal Cancer Patients.
Teh LK, Hamzah S, Hashim H, et al.
Ther Drug Monit. 2013 Aug 12. [Epub ahead of print]

The development of dasatinib as a treatment for chronic myeloid leukemia (CML): from initial studies to application in newly diagnosed patients.
Hochhaus A, Kantarjian H.
J Cancer Res Clin Oncol. 2013 Aug 13. [Epub ahead of print]

Recommendations for reporting results of diagnostic genetic testing (biochemical, cytogenetic and molecular genetic).
Claustres M, Kožich V, Dequeker E, et al.
Eur J Hum Genet. 2013 Aug 14. [Epub ahead of print]

C-KIT Signaling in Cancer Treatment.
Stankov K, Popovic S, Mikov M.
Curr Pharm Des. 2013 Aug 12. [Epub ahead of print]

Decreased Expression of AZGP1 Is Associated with Poor Prognosis in Primary Gastric Cancer.
Huang CY, Zhao JJ, Lv L, et al.
PLoS One. 2013 Jul 23;8(7):e69155.

Targeting BRAF in Multiple Myeloma.
O'Donnell E, Raje NS.
Cancer Discov. 2013 Aug;3(8):840-2.

Early Results Promising for LKD378 in ALK-positive NSCLC.
[No authors listed]
Cancer Discov. 2013 Aug;3(8):OF5.

Prognostic Value of EGFR Mutation and ERCC1 in Patients with Non-Small Cell Lung Cancer Undergoing Platinum-Based Chemotherapy.
Yamashita F, Azuma K, Yoshida T, et al.
PLoS One. 2013 Aug 5;8(8):e71356.

CD44 Gene Polymorphisms in Breast Cancer Risk and Prognosis: A Study in North Indian Population.
Tulsyan S, Agarwal G, Lal P, et al.
PLoS One. 2013 Aug 5;8(8):e71073.

Filed under

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.