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In Print: Recent Pharmacogenomics Papers of Note: Jul 24, 2013


Overexpressed transcription factor FOXM1 is a potential diagnostic and adverse prognostic factor in postoperational gastric cancer patients.
Li X, Qi W, Yao R, Tang D, Liang J.
Clin Transl Oncol. 2013 Jul 20. [Epub ahead of print]

Testing personalized medicine: patient and physician expectations of next-generation genomic sequencing in late-stage cancer care.
Miller FA, Hayeems RZ, Bytautas JP, et al.
Eur J Hum Genet. 2013 Jul 17. [Epub ahead of print]

Feasibility of Implementing a Comprehensive Warfarin Pharmacogenetics Service.
Nutescu EA, Drozda K, Bress AP, et al.
Pharmacotherapy. 2013 Jul 17. [Epub ahead of print]

Upregulation of microRNA-375 is associated with poor prognosis in pediatric acute myeloid leukemia.
Wang Z, Hong Z, Gao F, Feng W.
Mol Cell Biochem. 2013 Jul 18. [Epub ahead of print]

Circulating tumor cells predict progression-free and overall survival in Chinese patients with metastatic breast cancer, HER2-positive or triple-negative (CBCSG004): a multicenter, double-blind, prospective trial.
Jiang ZF, Cristofanilli M, Shao ZM, et al.
Ann Oncol. 2013 Jul 14. [Epub ahead of print]

Biomarker-based adaptive trials for patients with glioblastoma--lessons from I-SPY 2.
Alexander BM, Wen PY, Trippa L, et al.
Neuro Oncol. 2013 Aug;15(8):972-8. Epub 2013 Jul 14.

Genomic Alterations in Advanced Esophageal Cancer May Lead to Subtype-Specific Therapies.
Forde PM, Kelly RJ.
Oncologist. 2013 Jul 12. [Epub ahead of print]

Pharmacogenomics in pancreatic adenocarcinoma: new data and their clinical implications.
Strimpakos AS, Syrigos KN, Saif MW.
JOP. 2013 Jul 10;14(4):359-62.

A 92-gene cancer classifier predicts the site of origin for neuroendocrine tumors.
Kerr SE, Schnabel CA, Sullivan PS, et al.
Mod Pathol. 2013 Jul 12. [Epub ahead of print]

Prognostic and Putative Predictive Biomarkers of Gastric Cancer for Personalized Medicine.
Warneke VS, Behrens HM, Haag J, et al.
Diagn Mol Pathol. 2013 Jul 9. [Epub ahead of print]

Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor Dabrafenib (GSK2118436).
Nathanson KL, Martin AM, Wubbenhorst B, et al.
Clin Cancer Res. 2013 Jul 5. [Epub ahead of print]

Validation of a Proposed Warfarin Dosing Algorithm Based on the Genetic Make-Up of Egyptian Patients.
Ekladious SM, Issac MS, Sharaf SA, Abou-Youssef HS.
Mol Diagn Ther. 2013 Jul 10. [Epub ahead of print]

Validation study of a non-invasive urine test for diagnosis and prognosis assessment of bladder cancer. Evidence for improved models.
Mengual L, Ribal MJ, Lozano JJ, et al.
J Urol. 2013 Jul 2. [Epub ahead of print]

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The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.