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In Print: Recent PGx Papers


Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review.
Nielsen LM, Olesen AE, Branford R, et al.
Pain Pract. 2014 Sep 9. [Epub ahead of print]

Direct PCR: a new pharmacogenetic approach for the inexpensive testing of HLA-B*57:01.
Cascella R, Strafella C, Ragazzo M, et al.
Pharmacogenomics J. 2014 Sep 9. [Epub ahead of print]

Should mental health patients get pharmacogenomic testing?
Burns J.
Manag Care. 2014 Jul;23(7):28-30.

Pharmacogenomic Approach to Identify Drug Sensitivity in Small-Cell Lung Cancer.
Wildey G, Chen Y, Lent I, et al.
PLoS One. 2014 Sep 8;9(9):e106784.

High protein expression of EZH2 is related to unfavorable outcome to tamoxifen in metastatic breast cancer.
Reijm EA, Timmermans AM, Look MP, et al.
Ann Oncol. 2014 Sep 5 [Epub ahead of print]

Gene Variants in CYP2C19 are Associated with Altered In Vivo Bupropion Pharmacokinetics but not Bupropion Assisted Smoking Cessation Outcomes.
Zhu AZ, Zhou Q, Cox LS, et al.
Drug Metab Dispos. 2014 Sep 3. [Epub ahead of print]

Effect of CYP2C9-VKORC1 interaction on warfarin stable dosage and its predictive algorithm.
Li X, Liu R, Yan H, et al.
J Clin Pharmacol. 2014 Sep 4. [Epub ahead of print]

Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia.
Zgheib NK, Akra-Ismail M, Aridi C, et al.
Pharmacogenet Genomics. 2014 Aug;24(8):387-96.

Filed under

The Scan

RNA Editing in Octopuses Seems to Help Acclimation to Shifts in Water Temperature

A paper in Cell reports that octopuses use RNA editing to help them adjust to different water temperatures.

Topical Compound to Block EGFR Inhibitors May Ease Skin Toxicities, Study Finds

A topical treatment described in Science Translational Medicine may limit skin toxicities seen with EGFR inhibitor therapy.

Dozen Genetic Loci Linked to Preeclampsia Risk in New GWAS

An analysis of genome-wide association study data in JAMA Cardiology finds genetic loci linked to preeclampsia that have ties to blood pressure.

Cancer Survival Linked to Mutational Burden in Pan-Cancer Analysis

A pan-cancer paper appearing in JCO Precision Oncology suggests tumor mutation patterns provide clues for predicting cancer survival that are independent of other prognostic factors.