Skip to main content
Premium Trial:

Request an Annual Quote

Oxford BioDynamics, University of Glasgow Reach Epigenetic Biomarker Deal

NEW YORK (GenomeWeb News) – Oxford BioDynamics and the University of Glasgow today announced a partnership to identify biomarkers for the differentiation of responders from non-responders to methotrexate in the treatment of rheumatoid arthritis.

The deal allows the university to use OBD's EpiSwitch platform for the discovery and monitoring of highly specific epigenetic biomarkers called chromosome conformation signatures, which define and control important aspects of epigenetics and gene regulation. According to the firm, its EpiSwitch platform enables early detection of aberrant gene expression in very low copy numbers and in a small sample of abnormal cells.

The deal between OBD and the University of Glasgow, they said, will shed light on loci that are epigenetically unresponsive to methotrexate treatment, leading to a better understanding of the pathophysiology of rheumatoid arthritis.

Financial and other terms of the deal were not disclosed.

Last month OBD and the Genome Institute of Singapore reached a deal to identify epigenetic signatures in stem cells using the EpiSwitch platform.

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.