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MDx/CDx Focus: Arno Enrolling Patients in Second Onapristone Trial; Genewiz Launches PGxOne


Arno Enrolling Patients in Castration-Resistant Prostate Cancer Trial With Onapristone

Arno Therapeutics announced this week that researchers have enrolled the first patient in a Phase I/II trial evaluating onapristone in men with advanced, castration-resistant prostate cancer following failure on Zytiga (abiraterone) or Xtandi (enzalutamide).

Onapristone, an anti-progestin hormone blocker, is Arno's lead product. The drug has shown activity in Phase II studies against breast cancer. The drug is designed to block activation of the progesterone receptor which breast, endometrial and other tumors depend on to grow and advance. The company recently licensed technology from the University of Minnesota related to a gene signature that will enable it to detect activated progesterone and develop a companion test for gauging best responders to onapristone.

This study is the second Phase I trial involving onapristone to begin enrolling patients this year. In early March, Arno began enrolling patients in a Phase I dose escalation study investigating onapristone in post-menopausal women with progesterone receptor-positive breast, endometrial, and other solid tumors.

Genewiz Launches PGx Panel

Genewiz, a contract research organization providing genomic testing services, this week announced the launch of PGxOne, which helps doctors prescribe the drugs their patients are most likely to benefit from based on the genetic markers they harbor.

The pharmacogenomic panel is designed to run on both the Illumina MiSeq and the Ion Torrent PGM. The test gauges alterations in 25 clinically actionable genes, including markers in CYP, VKORC1, and SLCO1B1.

The Scan

Steps for Quick Review

The US Food and Drug Administration is preparing for the quick review of drugs and vaccines for the Omicron variant, according to the Wall Street Journal.

Moving Away From Using Term 'Race'

A new analysis finds that geneticists are using the term "race" in their papers less than in years past, as Science reports.

Point of the Program

The Guardian writes that some scientists have called the design of a UK newborn sequencing program into question.

Science Papers Present Multi-Omic Analysis of Lung Cells, Regulation of Cardiomyocyte Proliferation

In Science this week: a multi-omic analysis of lung cells focuses on RIT1-regulated pathways, and more.