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MDx/CDx Focus: Arno Enrolling Patients in Second Onapristone Trial; Genewiz Launches PGxOne


Arno Enrolling Patients in Castration-Resistant Prostate Cancer Trial With Onapristone

Arno Therapeutics announced this week that researchers have enrolled the first patient in a Phase I/II trial evaluating onapristone in men with advanced, castration-resistant prostate cancer following failure on Zytiga (abiraterone) or Xtandi (enzalutamide).

Onapristone, an anti-progestin hormone blocker, is Arno's lead product. The drug has shown activity in Phase II studies against breast cancer. The drug is designed to block activation of the progesterone receptor which breast, endometrial and other tumors depend on to grow and advance. The company recently licensed technology from the University of Minnesota related to a gene signature that will enable it to detect activated progesterone and develop a companion test for gauging best responders to onapristone.

This study is the second Phase I trial involving onapristone to begin enrolling patients this year. In early March, Arno began enrolling patients in a Phase I dose escalation study investigating onapristone in post-menopausal women with progesterone receptor-positive breast, endometrial, and other solid tumors.

Genewiz Launches PGx Panel

Genewiz, a contract research organization providing genomic testing services, this week announced the launch of PGxOne, which helps doctors prescribe the drugs their patients are most likely to benefit from based on the genetic markers they harbor.

The pharmacogenomic panel is designed to run on both the Illumina MiSeq and the Ion Torrent PGM. The test gauges alterations in 25 clinically actionable genes, including markers in CYP, VKORC1, and SLCO1B1.

The Scan

Nucleotide Base Detected on Near-Earth Asteroid

Among other intriguing compounds, researchers find the nucleotide uracil, a component of RNA sequences, in samples collected from the near-Earth asteroid Ryugu, as they report in Nature Communications.

Clinical Trial Participants, Investigators Point to Importance of Clinical Trial Results Reporting in Canadian Study

Public reporting on clinical trial results is crucial, according to qualitative interviews with clinical trial participants, investigators, and organizers from three provinces appearing in BMJ Open.

Old Order Amish Analysis Highlights Autozygosity, Potential Ties to Blood Measures

Researchers in BMC Genomics see larger and more frequent runs-of-homozygosity in Old Order Amish participants, though only regional autozygosity coincided with two blood-based measures.

Suicidal Ideation-Linked Loci Identified Using Million Veteran Program Data

Researchers in PLOS Genetics identify risk variants within and across ancestry groups with a genome-wide association study involving veterans with or without a history of suicidal ideation.