Skip to main content
Premium Trial:

Request an Annual Quote

Insight Genetics Snags $1.5M NCI Award for NSCLC Assay

NEW YORK (GenomeWeb News) — Insight Genetics said yesterday that it has received a new $1.5 million grant from the National Cancer Institute.

The Phase II Small Business Innovation Research grant from the National Cancer Institute will enable Nashville, Tenn.-based Insight to continue developing Insight ALK Resistance, a molecular diagnostic test to help clinicians monitor therapeutic resistance in non-small cell lung cancer patients.

Insight ALK Resistance is a customizable qPCR-based test that can detect all clinically identified resistance mutations in the ALK kinase domain or specific mutations, providing results within 48 hours and with minimal tissue requirement. The assay can be used for treatment efficacy monitoring, clinical decision making for alternative treatments, clinical trial enrollment for next-generation ALK inhibitors, or investigational academic research, and is currently offered as a laboratory-developed test by Insight Molecular Labs, the CLIA-certified subsidiary of Insight Genetics.

Insight Genetics obtained an exclusive worldwide license from St. Jude Children’s Research Hospital in 2010 for the detection of ALK inhibitor resistance mutations.

The new award is a continuation of a Phase I SBIR grant awarded to Insight in 2011, and is the company's sixth overall contract and third consecutive Phase II contract from NCI’s Companion Diagnostics program. In August, Insight was awarded a $1.5 million Phase II SBIR contract from NCI to continue development of a diagnostic test aimed at non-small cell lung cancer.

The Scan

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.

Lupus Heterogeneity Highlighted With Single-Cell Transcriptomes

Using single-cell RNA sequencing, researchers in Nature Communications tracked down immune and non-immune cell differences between discoid lupus erythematosus and systemic lupus erythematosus.

Rare Disease Clues Gleaned From Mobile Element Insertions in Exome Sequences

With an approach called MELT, researchers in the European Journal of Human Genetics uncovered mobile element insertions in exomes from 3,232 individuals with or without developmental or neurological abnormalities.

Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients

Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.