NEW YORK (GenomeWeb) – Researchers have conducted a genome-wide association study in children to retrospectively try to identify genetic markers that might predispose them to having greater post-operative pain, necessitating a higher morphine dose.

The study, the first of its kind in kids, analyzed samples from more than 600 children between ages four and 18 using Illumina arrays. The children hadn't been previously treated with opioids, and had been admitted to the hospital for day surgery for tonsillectomy and adenoidectomy.

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In PNAS this week: Akt3 amplification in glioma progression, Tibetan Plateau frog genome, and more.

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