Georgetown Team Planning Human Trial after Finding Targetable Marker of EGFR Inhibitor Resistance | GenomeWeb

NEW YORK (GenomeWeb) — A team led by researchers from the National Cancer Institute and Georgetown University has discovered that overexpression of the protein CRIPTO-1 is associated with intrinsic resistance to EGFR inhibition, and shown in early in vitro and in vivo experiments that targeting CRIPTO-1 using available or investigational drugs could improve patients' responses to anti-EGFR therapies.

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