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Researchers from the Broad Institute and MIT have used RNA editing and single-cell RNA sequencing to record when RNA molecules were transcribed.
The first stage generated a range of tools and resources for studying the nucleus in time and space including publicly available datasets and software.
The new plate-based protocol developed at the Karolinska Institute combines low-coverage WGS and SMART-Seq2 transcriptomics for single-cells.
10x will develop a third genomics platform, possibly combining Cartana's more sensitive chemistry with ReadCoor's instrument.
The transcriptomic study of human iPSC-derived dopaminergic neurons elucidated how gene expression changed in response to cytotoxic and genetic stressors.
The newly public company has attracted attention from both investors and competitors for its technology platform used in antibody discovery workflows.
The deals give 10x Genomics control of a combined 110 patents covering in situ analysis methods that the firm says will complement its existing platforms.
Using transcription data from cells and nuclei, the researchers uncovered heterogeneity within cardiac cells and mapped them to particular regions of the heart.
Single-cell RNA sequencing on adrenal gland samples with or without neuroblastoma helped track down key malignant subtypes and tumor features, providing prognostic clues.
The study found ciliated epithelial cells in the human endometrium undergo a sharp change in gene expression during the window of implantation.
The GTEx Consortium, which has been working for 10 years, analyzed how genetic variants affect gene regulation, and how this contributes to disease and traits.
UK-based ATDBio will develop new oligonucleotide-tagged microbeads for use in droplet-based single-cell RNA sequencing, to be evaluated by researchers at Oxford.
Instead of measuring metabolites directly, the researchers used mass cytometry and multiplexed ion beam imaging to measure proteins involved in metabolic regulation.
Labs are finding cheaper, higher-throughput ways to determine the inflection points in gene expression within a particular cell.
The European project will use single-cell profiling technologies to build well-characterized in vitro models of human organs and contribute to the Human Cell Atlas.
The de novo directional genomic hybridization technology is designed to enable the measurement of simple, complex, and heterogenous structural variants.
With single-cell transcriptomic, T cell receptor, and B cell receptor data, researchers tracked immune shifts in tissue and peripheral blood samples from ulcerative colitis patients.
Single-cell sequencing yielded transcriptomic profiles for more than 20,000 cells, revealing gene expression changes that occur in response to treatment.
Single-cell analysis identified different clusters of luminal cells in the prostate, one of which may contribute to the development of prostate cancer.
Tumor microenvironment cell transcriptomes pointed to four stromal cell clusters, including immune interacting support cells predicted to impact immunotherapy response.
NPR reports that researchers have developed chimeric embryos as part of work toward growing human organs in animals for organ transplants.
According to the Washington Post, the Biden Administration is set to make changes to federal restrictions on fetal tissue research.
In Science this week: approach to isolated trace DNA from archaic humans from sediments, and more.
Texas Monthly looks into the DNA Zoo being collected by Baylor College of Medicine researchers.