The first stage generated a range of tools and resources for studying the nucleus in time and space including publicly available datasets and software.
The transcriptomic study of human iPSC-derived dopaminergic neurons elucidated how gene expression changed in response to cytotoxic and genetic stressors.
The deals give 10x Genomics control of a combined 110 patents covering in situ analysis methods that the firm says will complement its existing platforms.
Using transcription data from cells and nuclei, the researchers uncovered heterogeneity within cardiac cells and mapped them to particular regions of the heart.
Single-cell RNA sequencing on adrenal gland samples with or without neuroblastoma helped track down key malignant subtypes and tumor features, providing prognostic clues.
The GTEx Consortium, which has been working for 10 years, analyzed how genetic variants affect gene regulation, and how this contributes to disease and traits.
UK-based ATDBio will develop new oligonucleotide-tagged microbeads for use in droplet-based single-cell RNA sequencing, to be evaluated by researchers at Oxford.
Instead of measuring metabolites directly, the researchers used mass cytometry and multiplexed ion beam imaging to measure proteins involved in metabolic regulation.
The European project will use single-cell profiling technologies to build well-characterized in vitro models of human organs and contribute to the Human Cell Atlas.
The de novo directional genomic hybridization technology is designed to enable the measurement of simple, complex, and heterogenous structural variants.
With single-cell transcriptomic, T cell receptor, and B cell receptor data, researchers tracked immune shifts in tissue and peripheral blood samples from ulcerative colitis patients.
Single-cell sequencing yielded transcriptomic profiles for more than 20,000 cells, revealing gene expression changes that occur in response to treatment.
Single-cell analysis identified different clusters of luminal cells in the prostate, one of which may contribute to the development of prostate cancer.
Tumor microenvironment cell transcriptomes pointed to four stromal cell clusters, including immune interacting support cells predicted to impact immunotherapy response.
