Developed by researchers at Yale University, the method, called deterministic barcoding in tissue sequencing, can map thousands of genes at 10 micron resolution.
The firm aims to launch an early-access program by the end of the year, followed by a second white paper before the JP Morgan Healthcare Conference in January.
Translational informatics company Paradigm4's new Reveal: SingleCell app is built on its core SciDB platform that supports fast querying of large multiomic datasets.
Targeted at drug development and clinical trials, the firm's new system allows the simultaneous collection of single-cell DNA and surface protein data.
The researchers noted an enrichment of chromosome 7 gains in fibroblasts from the tumor microenvironment and discovered expression biomarkers of poor prognosis.
The first stage generated a range of tools and resources for studying the nucleus in time and space including publicly available datasets and software.
The transcriptomic study of human iPSC-derived dopaminergic neurons elucidated how gene expression changed in response to cytotoxic and genetic stressors.
The deals give 10x Genomics control of a combined 110 patents covering in situ analysis methods that the firm says will complement its existing platforms.
Using transcription data from cells and nuclei, the researchers uncovered heterogeneity within cardiac cells and mapped them to particular regions of the heart.
Single-cell RNA sequencing on adrenal gland samples with or without neuroblastoma helped track down key malignant subtypes and tumor features, providing prognostic clues.
The GTEx Consortium, which has been working for 10 years, analyzed how genetic variants affect gene regulation, and how this contributes to disease and traits.
UK-based ATDBio will develop new oligonucleotide-tagged microbeads for use in droplet-based single-cell RNA sequencing, to be evaluated by researchers at Oxford.
