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Developed by researchers at Yale University, the method, called deterministic barcoding in tissue sequencing, can map thousands of genes at 10 micron resolution.
A new GeoMx Digital Spatial Profiler assay will have up to 30 protein targets and will be validated for potential use as a laboratory-developed test.
The firm aims to launch an early-access program by the end of the year, followed by a second white paper before the JP Morgan Healthcare Conference in January.
Translational informatics company Paradigm4's new Reveal: SingleCell app is built on its core SciDB platform that supports fast querying of large multiomic datasets.
Targeted at drug development and clinical trials, the firm's new system allows the simultaneous collection of single-cell DNA and surface protein data.
Researchers combined protein expression with mutational analysis to map the somatic genotype and clonal architecture of AML with its immunophenotype.
The researchers noted an enrichment of chromosome 7 gains in fibroblasts from the tumor microenvironment and discovered expression biomarkers of poor prognosis.
An MD Anderson-led team also used longitudinal single-cell sequencing to show how clonal architecture changed in response to AML treatment.
Researchers from the Broad Institute and MIT have used RNA editing and single-cell RNA sequencing to record when RNA molecules were transcribed.
The first stage generated a range of tools and resources for studying the nucleus in time and space including publicly available datasets and software.
The new plate-based protocol developed at the Karolinska Institute combines low-coverage WGS and SMART-Seq2 transcriptomics for single-cells.
10x will develop a third genomics platform, possibly combining Cartana's more sensitive chemistry with ReadCoor's instrument.
The transcriptomic study of human iPSC-derived dopaminergic neurons elucidated how gene expression changed in response to cytotoxic and genetic stressors.
The newly public company has attracted attention from both investors and competitors for its technology platform used in antibody discovery workflows.
The deals give 10x Genomics control of a combined 110 patents covering in situ analysis methods that the firm says will complement its existing platforms.
Using transcription data from cells and nuclei, the researchers uncovered heterogeneity within cardiac cells and mapped them to particular regions of the heart.
Single-cell RNA sequencing on adrenal gland samples with or without neuroblastoma helped track down key malignant subtypes and tumor features, providing prognostic clues.
The study found ciliated epithelial cells in the human endometrium undergo a sharp change in gene expression during the window of implantation.
The GTEx Consortium, which has been working for 10 years, analyzed how genetic variants affect gene regulation, and how this contributes to disease and traits.
UK-based ATDBio will develop new oligonucleotide-tagged microbeads for use in droplet-based single-cell RNA sequencing, to be evaluated by researchers at Oxford.
New analyses indicate the P.1 variant found in Brazil may be able to infect people who have already had COVID-19, the New York Times reports.
According to CNBC, Novavax's CEO says its vaccine could be authorized in the US as early as May.
The US National Institutes of Health has a new initiative to address structural racism in biomedical research.
In PNAS this week: GWAS of TLV-1-associated myelopathy/tropical spastic paraparesis, analysis of twins with hypertrophic cardiomyopathy, and more.