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More articles about Biomarker Discovery & Validation

Clinical proteomics may have a spotty and troubled history, but at the Human Proteome Organization's annual conference in Toronto, the push to move proteomics from the research lab to the clinical setting was everywhere to be seen.

The funding will support depression treatment biomarker studies and a bio-sample resource.

The most recent suit, filed last week, alleges that the researcher misrepresented and falsified data related to prostate cancer biomarkers after Onconome sponsored "millions of dollars" of research at his University of Pittsburgh and Johns Hopkins University labs to see if the technology could lead to a clinical diagnostic test for prostate cancer.

Brahms will provide Thermo Fisher with complementary diagnostic products and reagent manufacturing capabilities.

The firm got the loan from a now former member of its board of directors.

The biomarker was discovered by former UVA researcher and company co-founder Klaus Ley using a proteomics platform that he also developed while at the university and upon which MPP was founded.

The findings, published in JAMA, suggest that the biomarkers could pinpoint cases of incipient Alzheimer's with 83 percent sensitivity and 72 percent specificity. Nevertheless, those involved say it's too early to routinely use the biomarkers in the clinic.

OSI will have access to AVEO's tumor models, archives, and biomarkers and will also acquire non-exclusive access to AVEO's proprietary bioinformatics platform.

Individual labs have shown that multiple reaction monitoring coupled with isotope dilution mass spectrometry, or SID-MRM-MS, can be used to quantify candidate protein biomarkers in plasma, but until now no one had proven the interlaboratory reproducibility of the method or the transferability of the assays across different labs.

Two studies appearing in the latest issue of the Journal of the American Medical Association examine the applicability of cardiovascular biomarkers for diagnostic and therapeutic development.

DiaGenic licensed biomarkers for mild cognitive impairment to drug firm Merz Pharmaceuticals, which will use the biomarkers for recruiting patients for Alzheimer's disease drug trials.

Snippets: Apr 15, 2009


Decode Genetics, National Cancer Institute, Clinical Data, Beckman Coulter, Department of Veterans Affairs, Genetics and Public Policy Center, National Institute of Child Health and Human Development

Two new biomarker grant programs will fund research into early-stage targets and develop them toward clinical trials.

A new bill puts biomarkers and biorepositories for cancer research on the front burner.

Included is a paper on the use of a mass spectrometry-based strategy for the absolute quantification of protein complex components, one using SISCAPA technology, and one showing that top-down proteomics can be done using CID on a q-TOF instrument.

Monogram's annual revenues jumped 44 percent. Though the firm expects mid single-digit revenue growth for 2009, it has taken measures to cut $10 million of costs from its 2009 spending.

Entelos, GlaxoSmithKline, Insilicos, Sciformatix, E&K, EMBL, Genomatix, Fox Chase Cancer Center, BioDiscovery, Roche, Genedata


Politico reports that the NYPD DNA database has grown since it announced it would be removing profiles from it.

Forbes reports that a structural biology lab at Oxford University studying the coronavirus was hacked.

Science reports that a Dutch research funding agency is combating a ransomware attack.

In Science this week: set of 64 haplotype assemblies from 32 individuals, and more.